Cell selective cytotoxicity of a peptide toxin from the cyanobacterium Microcystis aeruginosa

John Eriksson, Henry Hägerstrand, Isomaa

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    42 Citeringar (Scopus)

    Sammanfattning

    The effects of a cyclic peptide toxin, isolated from the cyanobacterium Microcystis aeruginosa, on cell morphology and ion transport in human erythrocytes, isolated rat hepatocytes and mouse fibroblasts (3T3) were studied. Neither in erythrocytes nor in fibroblasts did the toxin cause morphological alterations. In hepatocytes the toxin induced marked morphological alterations at a concentration of about 50 nM. In erythrocytes and fibroblasts no effects on ion transport were observed. In hepatocytes the toxin induced a significant increase in both phosphate and potassium efflux at concentrations far below the concentration causing morphological alterations (0.1 and 1 nM, respectively). It is suggested that the cytotoxicity of the toxin is not due to a non-specific interaction with the plasma membrane and that the effects of the toxin in hepatocytes are probably due to an interaction of the toxin with cytoskeletal elements.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)304–310
    TidskriftBBA - Biochimica et Biophysica Acta
    Volym930
    Utgåva3
    StatusPublicerad - 1987
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Citera det här