Sammanfattning
Fully acetylated D- and L-alpha-mannosylacetaldehydes have been prepared and used as substrates to produce the corresponding cyanohydrins or cyanohydrin acetates with (2S) or (2R) configuration, respectively, at the cyanohydrin moiety. The (R)-oxynitrilase-catalysed synthesis and lipase-catalysed diastereomeric kinetic and dynamic kinetic resolutions were investigated. Sequential catalysis with almond meal [ an economic source of (R)-oxynitrilase] and Burkholderia cepacia lipase was shown to be a straightforward method that yielded the four diastereomeric target cyanohydrins, the absolute configurations of which were confirmed by (1)H NMR analysis.
Originalspråk | Odefinierat/okänt |
---|---|
Sidor (från-till) | 6974–6980 |
Antal sidor | 7 |
Tidskrift | European Journal of Organic Chemistry |
Utgåva | 36 |
DOI | |
Status | Publicerad - 2010 |
MoE-publikationstyp | A1 Tidskriftsartikel-refererad |
Nyckelord
- Diastereoselectivity
- Enzyme catalysis
- Kinetic resolution