Sammanfattning
Availability of the α2C-adrenoceptor (α2C-AR) positron emission tomography (PET) tracer, [11C]ORM-13070, and the α2C-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype in brain function, both in healthy humans and in patients with various brain disorders. This translational study employed [11C]ORM-13070 autoradiography and PET to determine α2C-AR occupancy by ORM-12741 in rat and human brain, respectively.
Originalspråk | Engelska |
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Tidskrift | EJNMMI Research |
Volym | 10 |
Nummer | 1 |
DOI | |
Status | Publicerad - 2020 |
MoE-publikationstyp | A1 Tidskriftsartikel-refererad |