ANOMALOUS DOSE-RESPONSE RELATIONSHIP DUE TO ASSOCIATION COLLOIDAL BEHAVIOUR OF SOLUBLE AMPHIPHILIC COMPOUNDS

B ISOMAA; Henry Hägerstrand; Diana Toivola

ANOMALOUS DOSE-RESPONSE RELATIONSHIP DUE TO ASSOCIATION COLLOIDAL BEHAVIOUR OF SOLUBLE AMPHIPHILIC COMPOUNDS

B ISOMAA, Henry Hägerstrand, Diana Toivola

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Sammanfattning

Water-soluble amphiphiles may, above a certain concentration, form colloidal aggregates (micelles or liquid crystals). If such aggregates are formed, there may be a competition between the micelles or the liquid crystals and the biological target for the monomeric form of the amphiphile. This may reduce the number of monomers available for the biological target, which in turn may be reflected in concentration-dependent processes. Therefore, caution should be taken when examining dose-response with soluble amphiphiles forming micelles at low concentrations.

Originalspråk	Odefinierat/okänt
Sidor (från-till)	194–198
Antal sidor	5
Tidskrift	Alternatives to Laboratory Animals
Volym	19
Status	Publicerad - 1991
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Nyckelord

AMPHIPHILE
DOSE-RESPONSE
CRITICAL MICELLE CONCENTRATION
hemolysis
erythrocyte membrane

Citera det här

@article{2758a95fedaf490a9009200f9b9e7c7c,

title = "ANOMALOUS DOSE-RESPONSE RELATIONSHIP DUE TO ASSOCIATION COLLOIDAL BEHAVIOUR OF SOLUBLE AMPHIPHILIC COMPOUNDS",

abstract = "Water-soluble amphiphiles may, above a certain concentration, form colloidal aggregates (micelles or liquid crystals). If such aggregates are formed, there may be a competition between the micelles or the liquid crystals and the biological target for the monomeric form of the amphiphile. This may reduce the number of monomers available for the biological target, which in turn may be reflected in concentration-dependent processes. Therefore, caution should be taken when examining dose-response with soluble amphiphiles forming micelles at low concentrations.",

keywords = "AMPHIPHILE, DOSE-RESPONSE, CRITICAL MICELLE CONCENTRATION, hemolysis, erythrocyte membrane, AMPHIPHILE, DOSE-RESPONSE, CRITICAL MICELLE CONCENTRATION, hemolysis, erythrocyte membrane, AMPHIPHILE, DOSE-RESPONSE, CRITICAL MICELLE CONCENTRATION, hemolysis, erythrocyte membrane",

author = "B ISOMAA and Henry H{\"a}gerstrand and Diana Toivola",

year = "1991",

language = "Odefinierat/ok{\"a}nt",

volume = "19",

pages = "194–198",

journal = "Alternatives to Laboratory Animals",

issn = "0261-1929",

publisher = "Fund for the Replacement of Animals in Medical Experiments (FRAME)",

}

TY - JOUR

T1 - ANOMALOUS DOSE-RESPONSE RELATIONSHIP DUE TO ASSOCIATION COLLOIDAL BEHAVIOUR OF SOLUBLE AMPHIPHILIC COMPOUNDS

AU - ISOMAA, B

AU - Hägerstrand, Henry

AU - Toivola, Diana

PY - 1991

Y1 - 1991

N2 - Water-soluble amphiphiles may, above a certain concentration, form colloidal aggregates (micelles or liquid crystals). If such aggregates are formed, there may be a competition between the micelles or the liquid crystals and the biological target for the monomeric form of the amphiphile. This may reduce the number of monomers available for the biological target, which in turn may be reflected in concentration-dependent processes. Therefore, caution should be taken when examining dose-response with soluble amphiphiles forming micelles at low concentrations.

AB - Water-soluble amphiphiles may, above a certain concentration, form colloidal aggregates (micelles or liquid crystals). If such aggregates are formed, there may be a competition between the micelles or the liquid crystals and the biological target for the monomeric form of the amphiphile. This may reduce the number of monomers available for the biological target, which in turn may be reflected in concentration-dependent processes. Therefore, caution should be taken when examining dose-response with soluble amphiphiles forming micelles at low concentrations.

KW - AMPHIPHILE

KW - DOSE-RESPONSE

KW - CRITICAL MICELLE CONCENTRATION

KW - hemolysis

KW - erythrocyte membrane

KW - AMPHIPHILE

KW - DOSE-RESPONSE

KW - CRITICAL MICELLE CONCENTRATION

KW - hemolysis

KW - erythrocyte membrane

KW - AMPHIPHILE

KW - DOSE-RESPONSE

KW - CRITICAL MICELLE CONCENTRATION

KW - hemolysis

KW - erythrocyte membrane

M3 - Artikel

SN - 0261-1929

VL - 19

SP - 194

EP - 198

JO - Alternatives to Laboratory Animals

JF - Alternatives to Laboratory Animals

ER -