Analysis of Label-Free Single-Molecule Biosensors based on Gate-Biofunctionalized Organic Transistors

F Torricelli, Eleonora Macchia, K Manoli, Di Franco C, ZM Kovacs-Vajna, G Palazzo, G Scamarcio, Luisa Torsi

Forskningsoutput: Kapitel i bok/konferenshandlingKonferensbidragVetenskapligPeer review


A label-free single-molecule detection platform based on biofunctionalized organic transistors has been recently proposed. In contrast to state-of-art approaches based on nano-transducers, the aforementioned single-molecule transistor (SiMoT) sensing technology is based on millimeter-sized transistors where the gate is bio-functionalized with about a trillion of antibodies. In this work we provide a detailed investigation of SiMoT biosensors by studying and quantifying the device parameters affected by the biorecognition event. The study combines both measurements and theoretical analyses, showing that a single protein detection taking place at nanometer scale affects a millimeter scale area of the biofunctionalized gate electrode. The dimension of the bioprobe domains affected by the binding is calculated as a function of the nominal protein concentration in the analyte solution. These results provide important insight into the SiMoT biosensor technology, which can guide the development of multi-modal SiMoT detection and integrated SiMoT biosensors arrays.
Titel på värdpublikation2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI)
Antal sidor5
ISBN (elektroniskt)978-1-7281-0557-4
ISBN (tryckt)978-1-7281-0558-1
StatusPublicerad - 2019
MoE-publikationstypA4 Artikel i en konferenspublikation
EvenemangInternational Workshop on Advances in Sensors and Interfaces - 8th International Workshop on Advances in Sensors and Interfaces
Varaktighet: 13 juni 201914 juni 2019


KonferensInternational Workshop on Advances in Sensors and Interfaces


  • biofunctionalization
  • biosensor
  • organic transistor
  • single molecule

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