An impedance QCM study on the partitioning of bioactive compounds in supported phospholipid bilayers

Klaara Kannisto; Lasse Murtomäki; Tapani Viitala

doi:10.1016/j.colsurfb.2011.04.012

An impedance QCM study on the partitioning of bioactive compounds in supported phospholipid bilayers

Klaara Kannisto
, Lasse Murtomäki^*
, Tapani Viitala

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

24 Citeringar (Scopus)

Sammanfattning

The interaction of two drugs of small molecular size, propranolol and tetracaine, and the membrane-perturbing peptide melittin with a phospholipid bilayer supported on a SiO₂ surface was studied with the quartz crystal microbalance. All three bioactive compounds interacted with the lipid bilayer and changed its viscoelastic properties. Adsorbed mass of the compounds was analyzed with a viscoelastic model as a function of the concentration of the compounds in the aqueous phase, as well as the effect of the compounds on the bilayer viscoelasticity. The analysis was based on the interpretation of the impedance of the crystal, utilizing the 5th, 7th and 9th overtone of the fundamental 5MHz resonance frequency.

Originalspråk	Engelska
Sidor (från-till)	298-304
Antal sidor	7
Tidskrift	Colloids and Surfaces B: Biointerfaces
Volym	86
Nummer	2
DOI	https://doi.org/10.1016/j.colsurfb.2011.04.012
Status	Publicerad - 1 sep. 2011
Externt publicerad	Ja
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Finansiering

Tapani Viitala acknowledges support from the Academy of Finland (grant nos. 137053 and 140980 ).

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10.1016/j.colsurfb.2011.04.012

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title = "An impedance QCM study on the partitioning of bioactive compounds in supported phospholipid bilayers",

abstract = "The interaction of two drugs of small molecular size, propranolol and tetracaine, and the membrane-perturbing peptide melittin with a phospholipid bilayer supported on a SiO2 surface was studied with the quartz crystal microbalance. All three bioactive compounds interacted with the lipid bilayer and changed its viscoelastic properties. Adsorbed mass of the compounds was analyzed with a viscoelastic model as a function of the concentration of the compounds in the aqueous phase, as well as the effect of the compounds on the bilayer viscoelasticity. The analysis was based on the interpretation of the impedance of the crystal, utilizing the 5th, 7th and 9th overtone of the fundamental 5MHz resonance frequency.",

keywords = "Adsorption, Phospholipid bilayer, Quartz crystal microbalance, Viscoelasticity",

author = "Klaara Kannisto and Lasse Murtom{\"a}ki and Tapani Viitala",

note = "Funding Information: Tapani Viitala acknowledges support from the Academy of Finland (grant nos. 137053 and 140980 ).",

year = "2011",

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doi = "10.1016/j.colsurfb.2011.04.012",

language = "English",

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journal = "Colloids and Surfaces B: Biointerfaces",

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AU - Kannisto, Klaara

AU - Murtomäki, Lasse

AU - Viitala, Tapani

N1 - Funding Information: Tapani Viitala acknowledges support from the Academy of Finland (grant nos. 137053 and 140980 ).

PY - 2011/9/1

Y1 - 2011/9/1

N2 - The interaction of two drugs of small molecular size, propranolol and tetracaine, and the membrane-perturbing peptide melittin with a phospholipid bilayer supported on a SiO2 surface was studied with the quartz crystal microbalance. All three bioactive compounds interacted with the lipid bilayer and changed its viscoelastic properties. Adsorbed mass of the compounds was analyzed with a viscoelastic model as a function of the concentration of the compounds in the aqueous phase, as well as the effect of the compounds on the bilayer viscoelasticity. The analysis was based on the interpretation of the impedance of the crystal, utilizing the 5th, 7th and 9th overtone of the fundamental 5MHz resonance frequency.

AB - The interaction of two drugs of small molecular size, propranolol and tetracaine, and the membrane-perturbing peptide melittin with a phospholipid bilayer supported on a SiO2 surface was studied with the quartz crystal microbalance. All three bioactive compounds interacted with the lipid bilayer and changed its viscoelastic properties. Adsorbed mass of the compounds was analyzed with a viscoelastic model as a function of the concentration of the compounds in the aqueous phase, as well as the effect of the compounds on the bilayer viscoelasticity. The analysis was based on the interpretation of the impedance of the crystal, utilizing the 5th, 7th and 9th overtone of the fundamental 5MHz resonance frequency.

KW - Adsorption

KW - Phospholipid bilayer

KW - Quartz crystal microbalance

KW - Viscoelasticity

UR - https://www.scopus.com/pages/publications/79957635899

U2 - 10.1016/j.colsurfb.2011.04.012

DO - 10.1016/j.colsurfb.2011.04.012

M3 - Article

C2 - 21549577

AN - SCOPUS:79957635899

SN - 0927-7765

VL - 86

SP - 298

EP - 304

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 2

ER -

An impedance QCM study on the partitioning of bioactive compounds in supported phospholipid bilayers

Sammanfattning

Finansiering

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