An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity

Helinä Kahma; Laura Aurinsalo; Mikko Neuvonen; Jani Katajamäki; Marie-Noëlle Paludetto; Jenni Viinamäki; Terhi Launiainen; Anne M. Filppula; Aleksi Tornio; Mikko Niemi; Janne T. Backman

doi:10.1016/j.ejps.2021.105810

An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity

Helinä Kahma, Laura Aurinsalo, Mikko Neuvonen, Jani Katajamäki, Marie-Noëlle Paludetto, Jenni Viinamäki, Terhi Launiainen, Anne M. Filppula, Aleksi Tornio, Mikko Niemi, Janne T. Backman

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	Engelska
Artikelnummer	105810
Tidskrift	European Journal of Pharmaceutical Sciences
Volym	162
DOI	https://doi.org/10.1016/j.ejps.2021.105810
Status	Publicerad - jul 2021
Externt publicerad	Ja
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Åtkomst av dokument

10.1016/j.ejps.2021.105810

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https://doi.org/10.1016/j.ejps.2021.105810

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Kahma, H., Aurinsalo, L., Neuvonen, M., Katajamäki, J., Paludetto, M-N., Viinamäki, J., Launiainen, T., Filppula, A. M., Tornio, A., Niemi, M., & Backman, J. T. (2021). An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. European Journal of Pharmaceutical Sciences, 162, [105810]. https://doi.org/10.1016/j.ejps.2021.105810

Kahma, Helinä ; Aurinsalo, Laura ; Neuvonen, Mikko ; Katajamäki, Jani ; Paludetto, Marie-Noëlle ; Viinamäki, Jenni ; Launiainen, Terhi ; Filppula, Anne M. ; Tornio, Aleksi ; Niemi, Mikko ; Backman, Janne T. / An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. I: European Journal of Pharmaceutical Sciences. 2021 ; Vol. 162.

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title = "An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity",

author = "Helin{\"a} Kahma and Laura Aurinsalo and Mikko Neuvonen and Jani Katajam{\"a}ki and Marie-No{\"e}lle Paludetto and Jenni Viinam{\"a}ki and Terhi Launiainen and Filppula, {Anne M.} and Aleksi Tornio and Mikko Niemi and Backman, {Janne T.}",

year = "2021",

month = jul,

doi = "10.1016/j.ejps.2021.105810",

language = "English",

volume = "162",

journal = "European Journal of Pharmaceutical Sciences",

issn = "0928-0987",

publisher = "Elsevier",

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Kahma, H, Aurinsalo, L, Neuvonen, M, Katajamäki, J, Paludetto, M-N, Viinamäki, J, Launiainen, T, Filppula, AM, Tornio, A, Niemi, M & Backman, JT 2021, 'An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity', European Journal of Pharmaceutical Sciences, vol. 162, 105810. https://doi.org/10.1016/j.ejps.2021.105810

An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. / Kahma, Helinä; Aurinsalo, Laura; Neuvonen, Mikko; Katajamäki, Jani; Paludetto, Marie-Noëlle; Viinamäki, Jenni; Launiainen, Terhi; Filppula, Anne M.; Tornio, Aleksi; Niemi, Mikko; Backman, Janne T.

I: European Journal of Pharmaceutical Sciences, Vol. 162, 105810, 07.2021.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

TY - JOUR

T1 - An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity

AU - Kahma, Helinä

AU - Aurinsalo, Laura

AU - Neuvonen, Mikko

AU - Katajamäki, Jani

AU - Paludetto, Marie-Noëlle

AU - Viinamäki, Jenni

AU - Launiainen, Terhi

AU - Filppula, Anne M.

AU - Tornio, Aleksi

AU - Niemi, Mikko

AU - Backman, Janne T.

PY - 2021/7

Y1 - 2021/7

UR - https://doi.org/10.1016/j.ejps.2021.105810

U2 - 10.1016/j.ejps.2021.105810

DO - 10.1016/j.ejps.2021.105810

M3 - Article

VL - 162

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

M1 - 105810

ER -

Kahma H, Aurinsalo L, Neuvonen M, Katajamäki J, Paludetto M-N, Viinamäki J et al. An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. European Journal of Pharmaceutical Sciences. 2021 jul;162. 105810. https://doi.org/10.1016/j.ejps.2021.105810