A simple mass-action model for the eukaryotic heat shock response and its mathematical validation

Ion Petre, A Mizera, Claire Hyder, Annika Meinander, A Mikhailov, RI Morimoto, Lea Sistonen, John Eriksson, RJ Back

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    41 Citeringar (Scopus)

    Sammanfattning

    The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides a useful foundation for modeling strategies of more complex cellular processes.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)595–612
    Antal sidor18
    TidskriftNatural Computing
    Volym10
    Utgåva1
    DOI
    StatusPublicerad - 2011
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Nyckelord

    • Heat shock element
    • Heat shock factor
    • Heat shock protein
    • Heat shock response
    • Mathematical model
    • Regulatory network

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