A New Mathematical Model for the Heat Shock Response

Ion Petre; A Mizera; Claire Hyder; A Mikhailov; John Eriksson; Lea Sistonen; Ralph-Johan Back

doi:10.1007/978-3-540-88869-7_21

A New Mathematical Model for the Heat Shock Response

Ion Petre, A Mizera, Claire Hyder, A Mikhailov, John Eriksson, Lea Sistonen, Ralph-Johan Back

Forskningsoutput: Kapitel i bok/konferenshandling › Kapitel › Vetenskaplig › Peer review

9 Citeringar (Scopus)

Sammanfattning

We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.

Originalspråk	Odefinierat/okänt
Titel på värdpublikation	Algorithmic bioprocesses
Redaktörer	Anne Condon, David Harel, Joost N. Kok, Arto Salomaa, Erik Winfree
Förlag	Springer
Sidor	411–425
Antal sidor	15
ISBN (tryckt)	9783540888697
DOI	https://doi.org/10.1007/978-3-540-88869-7_21
Status	Publicerad - 2009
MoE-publikationstyp	A3 Del av bok eller annan forskningsbok

Åtkomst av dokument

10.1007/978-3-540-88869-7_21

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abstract = "We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.",

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AU - Petre, Ion

AU - Mizera, A

AU - Hyder, Claire

AU - Mikhailov, A

AU - Eriksson, John

AU - Sistonen, Lea

AU - Back, Ralph-Johan

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