A New Mathematical Model for the Heat Shock Response

Ion Petre, A Mizera, Claire Hyder, A Mikhailov, John Eriksson, Lea Sistonen, Ralph-Johan Back

    Forskningsoutput: Kapitel i bok/konferenshandlingKapitelVetenskapligPeer review

    9 Citeringar (Scopus)

    Sammanfattning

    We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.
    OriginalspråkOdefinierat/okänt
    Titel på gästpublikationAlgorithmic bioprocesses
    RedaktörerAnne Condon, David Harel, Joost N. Kok, Arto Salomaa, Erik Winfree
    FörlagSpringer
    Sidor411–425
    Antal sidor15
    ISBN (tryckt)9783540888697
    DOI
    StatusPublicerad - 2009
    MoE-publikationstypA3 Del av bok eller annan forskningsbok

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