Sammanfattning
We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells' proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.
Originalspråk | Odefinierat/okänt |
---|---|
Sidor (från-till) | 7066–7075 |
Antal sidor | 10 |
Tidskrift | Journal of Materials Chemistry. B |
Volym | 6 |
Nummer | 43 |
DOI | |
Status | Publicerad - 2018 |
MoE-publikationstyp | A1 Tidskriftsartikel-refererad |