TY - GEN
T1 - 3D label free bio-transfer standards
AU - Järvinen, Miikka
AU - Vainikka, Tuomas
AU - Viitala, Tapani
AU - Bermudez, Carlos
AU - Artigas, Roger
AU - Nolvi, Anton
AU - Martinez, Pol
AU - Sandler, Niklas
AU - Hæggström, Edward
AU - Kassamakov, Ivan
N1 - Publisher Copyright:
© 2018 SPIE.
PY - 2018
Y1 - 2018
N2 - Two kinds of 3D label free Bio-Transfer-Standards (BTS) have been further developed at the University of Helsinki (UH). The first one, NanoRuler, is a staircase BTS featuring eight fatty acid bilayers which allows vertical calibration in the range of 5 to 40 nm. The second one, NanoStar, is a V-shaped BTS featuring two 5 nm tall bilayers that overlap at 10° angle. This standard enables the determination of the Instrument Transfer Function (ITF). A stability test was conducted on the BTSs, during which the standards were stored in laboratory conditions, and were profiled each week. Profiling was done using a custom-built Scanning White Light Interferometer (SWLI). The stability of NanoStar was ± 0.3 nm, and of NanoRuler ± 0.5 nm to ± 2.5 nm. The BTSs maintained their specified properties for at least six months and therefore allow vertical calibration and ITF determination. In addition, changes in surface morphology of one NanoRuler subjected to water immersion are presented. This paper reports intermediate findings during an ongoing stability test that will run for 24 months.
AB - Two kinds of 3D label free Bio-Transfer-Standards (BTS) have been further developed at the University of Helsinki (UH). The first one, NanoRuler, is a staircase BTS featuring eight fatty acid bilayers which allows vertical calibration in the range of 5 to 40 nm. The second one, NanoStar, is a V-shaped BTS featuring two 5 nm tall bilayers that overlap at 10° angle. This standard enables the determination of the Instrument Transfer Function (ITF). A stability test was conducted on the BTSs, during which the standards were stored in laboratory conditions, and were profiled each week. Profiling was done using a custom-built Scanning White Light Interferometer (SWLI). The stability of NanoStar was ± 0.3 nm, and of NanoRuler ± 0.5 nm to ± 2.5 nm. The BTSs maintained their specified properties for at least six months and therefore allow vertical calibration and ITF determination. In addition, changes in surface morphology of one NanoRuler subjected to water immersion are presented. This paper reports intermediate findings during an ongoing stability test that will run for 24 months.
KW - Bio transfer standard
KW - Instrument Transfer Function
KW - Nanometer scale metrology
KW - Optical profiler
KW - Scanning White Light Interferometry
UR - https://www.scopus.com/pages/publications/85059394584
U2 - 10.1117/12.2501258
DO - 10.1117/12.2501258
M3 - Published conference proceeding
SN - 9781510622364
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Optical Metrology and Inspection for Industrial Applications V
A2 - Yoshizawa, Toru
A2 - Zhang, Song
A2 - Han, Sen
A2 - Han, Sen
PB - SPIE, The International Society for Optical Engineering
T2 - Optical Metrology and Inspection for Industrial Applications V 2018
Y2 - 11 October 2018 through 13 October 2018
ER -