Disturbed proteostasis may contribute to Parkinson’s disesase where deficient clearance of misfolded alpha-synuclein contributes to the pathology. Cells under stress are affected by this by a variety of mechanisms. From translational infidelity to usage of alternative start sites, the resulting protein aberrancies remain undetected by standard proteomics methods. This project will apply new methods to re-analyse existing proteomic data from Parkinson’s patient cohorts to uncover hidden proteome aberrancies within.
|Kort titel||MJFF Datascience|
|Gällande start-/slutdatum||01/06/22 → 31/01/24|
- Michael J. Fox Foundation: 287 071,00 €