Projektinformation
Beskrivning
Disturbed proteostasis may contribute to Parkinson’s disesase where deficient clearance of misfolded alpha-synuclein contributes to the pathology. Cells under stress are affected by this by a variety of mechanisms. From translational infidelity to usage of alternative start sites, the resulting protein aberrancies remain undetected by standard proteomics methods. This project will apply new methods to re-analyse existing proteomic data from Parkinson’s patient cohorts to uncover hidden proteome aberrancies within.
Kort titel | MJFF Datascience |
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Status | Pågående |
Gällande start-/slutdatum | 01/06/22 → 31/01/24 |
Finansiering
- Michael J. Fox Foundation: 287 071,00 €