Projekt per år
Personlig profil
Forskningsintressen
My research team at the Structural Bioinformatics Laboratory (SBL) focuses 3D structures of proteins and, particularly, utilizing 3D structures to predict and understand protein function. Our research on the molecular mechanism of infection, inflammation and cancer intertwines crystallography with computational modeling approaches. We aim to find out how proteins interact with other molecules and what is the structural basis for their ligand selectivity. The proteins we are working with are drug targets, off-targets, biomarkers of disease stages, biocatalysts or targets for diagnostics of disease.
Fingeravtryck
- 5 Liknande profiler
Nätverk
Projekt
- 1 Aktiv
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InFLAMES: Innovation Ecosystem based on the Immune System
Takeda, A., Marjamäki, A., Roivainen, A., Hakanen, A., Hänninen, A., Sahlgren, C., Julkunen, I., Ivaska, J., Eriksson, J., Jorma, T., Rinne, J., Knuuti, J., Westermarck, J., Jyrki, H., Gidwani, K., Elima, K., Aires, L., Elo, L. L., Hollmen, M., Johnson, M. S., Salmi, M., Oresic, M., Poutanen, M., Kortelainen, M., Pentikäinen, O., Raitakari, O., Jaakkola, P., Salminen, P., Taimen, P., Vallittu, P., Rantakari, P., Mattila, P., Nuutila, P., He, Q., Lahesmaa, R., De Figueiredo, R., Jalkanen, S., Lönnberg, T., Soukka, T., Salminen, T., Veromaa, T., Lamminmäki, U., Launis, V., Peltola, V. & Xiang-Guo, L.
01/07/20 → 30/04/23
Projekt: Forskning
Publikationer
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A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community)
Orengo, C., Velankar, S., Wodak, S., Zoete, V., Bonvin, A. M. J. J., Elofsson, A., Feenstra, K. A., Gerloff, D. L., Hamelryck, T., Hancock, J. M., Helmer-Citterich, M., Hospital, A., Orozco, M., Perrakis, A., Rarey, M., Soares, C., Sussman, J. L., Thornton, J. M., Tuffery, P., Tusnady, G. & 3 andra, , 2020, I: f1000research. 9, 278Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgång -
Candida antarctica Lipase A-Based Enantiorecognition of a Highly Strained 4-Dibenzocyclooctynol (DIBO) Used for PET Imaging
Sirén, S., Dahlström, K. M., Puttreddy, R., Rissanen, K., Salminen, T. A., Scheinin, M., Li, X-G. & Liljeblad, A., 17 feb 2020, I: Molecules. 25, 4, 879.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgång -
Evolution-guided engineering of non-heme iron enzymes involved in nogalamycin biosynthesis
Wandi, BN., Siitonen, V., Dinis, P., Vukic, V., Salminen, T. & Metsa-Ketela, M., 2020, I: FEBS Journal. 287, 14, s. 2998-3011 14 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Human Copper-Containing Amine Oxidases in Drug Design and Development
Vakal, S., Jalkanen, S., Dahlström, K. M. & Salminen, T. A., 12 mar 2020, I: Molecules. 25, 6, 1293.Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review
Öppen tillgång -
Human diamine oxidase cellular binding and internalization in vitro and rapid clearance in vivo are not mediated by N-glycans but by heparan sulfate proteoglycan interactions
Gludovacz, E., Schuetzenberger, K., Resch, M., Tillmann, K., Petroczi, K., Vondra, S., Vakal, S., Schosserer, M., Virgolini, N., Pollheimer, J., Salminen, T. A., Jilma, B., Borth, N. & Boehm, T., 2020, I: Glycobiology.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review