Abstrakti
Two proteins, D-alanine:D-alanine ligase and cAMP-dependent protein kinase, share a remarkable degree of structural convergence despite having different three-dimensional folds and different enzymatic functions. Here we report that as many as 103 residues from 10 segments form two identical super-secondary structures between which the cofactor ATP is bound. The cofactor, two bound metal cations, and several water molecules form a large network of electrostatic and hydrophobic interactions common to both enzymes, and these are mediated by the similar placement of equivalent amino acids within the common supersecondary structures.
Alkuperäiskieli | Ei tiedossa |
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Sivut | 1136–1146 |
Julkaisu | Protein Science |
Vuosikerta | 7 |
Numero | 5 |
DOI - pysyväislinkit | |
Tila | Julkaistu - 1998 |
OKM-julkaisutyyppi | A1 Julkaistu artikkeli, soviteltu |