Towards clinical PET imaging of pancreatic beta cells with [F-18]exendin-4

K Mikkola; CB Yim; P Lehtiniemi; VV Elomaa; T Ishizu; Johan Rajander; O Solin; P Nuutila

doi:10.1007/s00125-014-3355-0

Towards clinical PET imaging of pancreatic beta cells with [F-18]exendin-4

K Mikkola, CB Yim, P Lehtiniemi, VV Elomaa, T Ishizu, Johan Rajander, O Solin, P Nuutila

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

1 Sitaatiot (Scopus)

Abstrakti

[18F]exendin-4 is a radioligand specific for the gluca- gon like peptide-1 receptor (GLP-1R) abundantly expressed in beta cells. Quantitative non-invasive PET (positron emission tomography) imaging of pancreatic beta cells would serve as a valuable diagnostic tool and provide means to monitor therapeutic interventions. Several exendin based tracers have been intensively explored for beta cell imaging. The obstacle with these has been high uptake in the kidneys. The aim of this study is to develop a novel [18F]exendin-4 tracer for clinical imaging of beta cells with PET.

Alkuperäiskieli	Ei tiedossa
Sivut	S188–S188
Sivumäärä	1
Julkaisu	Diabetologia
Vuosikerta	57
DOI - pysyväislinkit	https://doi.org/10.1007/s00125-014-3355-0
Tila	Julkaistu - 2014
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

Pääsy asiakirjaan

10.1007/s00125-014-3355-0

http://download.springer.com/static/pdf/129/art%253A10.1007%252Fs00125-014-3355-0.pdf?auth66=1424091151_9c6fef32a3e975cc5627c2a3c7cbba02&ext=.pdf

Viittausmuodot

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abstract = "[18F]exendin-4 is a radioligand specific for the gluca- gon like peptide-1 receptor (GLP-1R) abundantly expressed in beta cells. Quantitative non-invasive PET (positron emission tomography) imaging of pancreatic beta cells would serve as a valuable diagnostic tool and provide means to monitor therapeutic interventions. Several exendin based tracers have been intensively explored for beta cell imaging. The obstacle with these has been high uptake in the kidneys. The aim of this study is to develop a novel [18F]exendin-4 tracer for clinical imaging of beta cells with PET. ",

author = "K Mikkola and CB Yim and P Lehtiniemi and VV Elomaa and T Ishizu and Johan Rajander and O Solin and P Nuutila",

year = "2014",

doi = "10.1007/s00125-014-3355-0",

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TY - JOUR

T1 - Towards clinical PET imaging of pancreatic beta cells with [F-18]exendin-4

AU - Mikkola, K

AU - Yim, CB

AU - Lehtiniemi, P

AU - Elomaa, VV

AU - Ishizu, T

AU - Rajander, Johan

AU - Solin, O

AU - Nuutila, P

PY - 2014

Y1 - 2014

N2 - [18F]exendin-4 is a radioligand specific for the gluca- gon like peptide-1 receptor (GLP-1R) abundantly expressed in beta cells. Quantitative non-invasive PET (positron emission tomography) imaging of pancreatic beta cells would serve as a valuable diagnostic tool and provide means to monitor therapeutic interventions. Several exendin based tracers have been intensively explored for beta cell imaging. The obstacle with these has been high uptake in the kidneys. The aim of this study is to develop a novel [18F]exendin-4 tracer for clinical imaging of beta cells with PET.

AB - [18F]exendin-4 is a radioligand specific for the gluca- gon like peptide-1 receptor (GLP-1R) abundantly expressed in beta cells. Quantitative non-invasive PET (positron emission tomography) imaging of pancreatic beta cells would serve as a valuable diagnostic tool and provide means to monitor therapeutic interventions. Several exendin based tracers have been intensively explored for beta cell imaging. The obstacle with these has been high uptake in the kidneys. The aim of this study is to develop a novel [18F]exendin-4 tracer for clinical imaging of beta cells with PET.

U2 - 10.1007/s00125-014-3355-0

DO - 10.1007/s00125-014-3355-0

M3 - Artikel

SN - 0012-186X

VL - 57

SP - S188–S188

JO - Diabetologia

JF - Diabetologia

ER -