The molecular biophysics of extracellular vimentin and its role in pathogen–host interactions

Sepideh Parvanian; Leila S. Coelho-Rato; John E. Eriksson; Alison E. Patteson

doi:10.1016/j.ceb.2023.102233

The molecular biophysics of extracellular vimentin and its role in pathogen–host interactions

Sepideh Parvanian
, Leila S. Coelho-Rato
, John E. Eriksson
, Alison E. Patteson^*

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Lehtiartikkeli › Katsausartikkeli › vertaisarvioitu

12 Sitaatiot (Scopus)

78 Lataukset (Pure)

Abstrakti

Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.

Alkuperäiskieli	Englanti
Artikkeli	102233
Sivumäärä	8
Julkaisu	Current Opinion in Cell Biology
Vuosikerta	85
DOI - pysyväislinkit	https://doi.org/10.1016/j.ceb.2023.102233
Tila	Julkaistu - jouluk. 2023
OKM-julkaisutyyppi	A2 Katsausartikkeli tiedejulkaisuussa (artikkeli)

Rahoitus

This work was supported by Academy of Finland , Sigrid Jusélius Foundation , Magnus Ehrnrooth Foundation , the Endowment of the Åbo Akademi University , K. Albin Johanssons stiftelse , Maud Kuistila Memorial Foundation , Liv och Hälsa Foundation , Otto A Malm Foundation , Finnish Cultural Foundation , Swedish Cultural Foundation , Ella and Georg Ehrnrooth Foundation and the Foundation “Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse” . This work was also supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R35GM142963 and National Science Foundation award number MCB 2026747 granted to AP. We thank Solveig Eriksson for the help with the graphical design. Graphics were created with BioRender.com .

Pääsy asiakirjaan

10.1016/j.ceb.2023.102233

Parvanian et alHyväksytty kirjoittajan käsikirjoitus, 813 KBLisenssi: CC BY-NC-ND

https://urn.fi/URN:NBN:fi-fe2024120198220

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title = "The molecular biophysics of extracellular vimentin and its role in pathogen{\textendash}host interactions",

abstract = "Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.",

author = "Sepideh Parvanian and Coelho-Rato, \{Leila S.\} and Eriksson, \{John E.\} and Patteson, \{Alison E.\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = dec,

doi = "10.1016/j.ceb.2023.102233",

language = "English",

volume = "85",

journal = "Current Opinion in Cell Biology",

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TY - JOUR

T1 - The molecular biophysics of extracellular vimentin and its role in pathogen–host interactions

AU - Parvanian, Sepideh

AU - Coelho-Rato, Leila S.

AU - Eriksson, John E.

AU - Patteson, Alison E.

PY - 2023/12

Y1 - 2023/12

N2 - Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.

AB - Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.

UR - https://www.scopus.com/pages/publications/85172383196

U2 - 10.1016/j.ceb.2023.102233

DO - 10.1016/j.ceb.2023.102233

M3 - Review Article or Literature Review

C2 - 37677998

AN - SCOPUS:85172383196

SN - 0955-0674

VL - 85

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

M1 - 102233

ER -

The molecular biophysics of extracellular vimentin and its role in pathogen–host interactions

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