The cytoskeleton of digestive epithelia in health and disease

Ku NO, XJ Zhou, Diana Toivola, MB Omary

Tutkimustuotos: LehtiartikkeliKatsausartikkelivertaisarvioitu

177 Sitaatiot (Scopus)

Abstrakti

The mammalian cell cytoskeleton consists of a diverse group of fibrillar elements that play a pivotal role in mediating a number of digestive and nondigestive cell functions, including secretion, absorption, motility, mechanical integrity, and mitosis. The cytoskeleton of higher-eukaryotic cells consists of three highly abundant major protein families: microfilaments (MF), microtubules (MT), and intermediate filaments (IF), as well as a growing number of associated proteins. Within digestive epithelia, the prototype members of these three protein families are actins, tubulins, and keratins, respectively. This review highlights the important structural, regulatory, functional, and unique features of the three major cytoskeletal protein groups in digestive epithelia. The emerging exciting biological aspects of these protein groups are their involvement in cell signaling via direct or indirect interaction with a growing list of associated proteins (MF, MT, IF), the identification of several disease-causing mutations (IF, MF), the functional role that they play in protection from environmental stresses (IF), and their functional integration via several linker proteins that bridge two or potentially ail three of these groups together. The use of agents that target specific cytoskeletal elements as therapeutic modalities for digestive diseases offers potential unique areas of intervention that remain to be fully explored.
AlkuperäiskieliEi tiedossa
SivutG1108–G1137
Sivumäärä30
JulkaisuAJP - Gastrointestinal and Liver Physiology
Vuosikerta277
Numero6
DOI - pysyväislinkit
TilaJulkaistu - 1999
OKM-julkaisutyyppiA2 Arvio tiedejulkaisuussa (artikkeli)

Keywords

  • microfilaments
  • microtubules
  • tubulin
  • intermediate filaments
  • keratins

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