Tailoring of Proteostasis Networks with Heat Shock Factors

Jenny Joutsen, Lea Sistonen

Tutkimustuotos: LehtiartikkeliKatsausartikkeliTieteellinenvertaisarvioitu

31 Sitaatiot (Scopus)

Abstrakti

Heat shock factors (HSFs) are the main transcriptional regulators of the heat shock response and indispensable for maintaining cellular proteostasis. HSFs mediate their protective functions through diverse genetic programs, which are composed of genes encoding molecular chaperones and other genes crucial for cell survival. The mechanisms that are used to tailor HSF-driven proteostasis networks are not yet completely understood, but they likely comprise from distinct combinations of both genetic and proteomic determinants. In this review, we highlight the versatile HSF-mediated cellular functions that extend from cellular stress responses to various physiological and pathological processes, and we underline the key advancements that have been achieved in the field of HSF research during the last decade.
AlkuperäiskieliEi tiedossa
Sivut
Sivumäärä17
JulkaisuCold Spring Harbor Perspectives in Biology
Vuosikerta11
DOI - pysyväislinkit
TilaJulkaistu - 2019
OKM-julkaisutyyppiA2 Arvio tiedejulkaisuussa (artikkeli)

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