Conclusions: The incorporated MAL linkage in [Cu-64]NODAGA-MAL-exendin-4 was unable to reduce kidney radioactivity levels, compared to [Cu-64]NODAGA-exendin-4. The applicability of metabolizable linkages in the design of kidney-saving exendin-4 analogs requires further investigation. (C) 2013 Elsevier Inc. All rights reserved.
- GLP-1 receptor
- Renal brush border membrane