@article{9ab231a633f7434baf565dddab9d9812,
title = "Synthesis and organotropism of 3H-dihydro derivatives of the cyanobacterial peptide hepatotoxin nodularin",
abstract = "Tritium-labelled dihydro derivatives of the cyanobacterial peptide hepatotoxin nodularin were prepared by reduction with sodium boro[3H]hydride. The optimised reaction gave two dihydronodularin stereoisomers which were purified by high-performance liquid chromatography with a mobile phase of methanol-0.7% sodium sulfate (6:4) and a C18 stationary phase. The specific activities of the stereoisomers were 1780-1807 dis min-1 ng-1. The radiolabelled dihydronodularins were tested for stability and used for toxicokinetic studies in mice. Liver was the main site of toxin accumulation.",
keywords = "Cyanobacteria, Nodularin, Organotropism, Radiolabelling, Toxin",
author = "Lisa Spoof and Svetlana Klimova and Andrey Mikhailov and Eriksson, {John E.} and Jussi Meriluoto",
note = "Funding Information: The authors gratefully acknowledge financial support from the Academy of Finland, RC for Natural Sciences and Engineering, project 47664 (JM, LS), Magnus Ehrnrooths stiftelse (LS), Oskar {\"O}flunds stiftelse (LS) and Stiftelsens f{\"o}r {\AA}bo Akademi forskningsinstitut (LS). Dr Leif Kronberg is thanked for help with MS, Jeanette Wikman for MMPB analyses and Miina Karjalainen for the determination of the specific activities of the compounds. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",
year = "2003",
month = feb,
day = "1",
doi = "10.1016/S0041-0101(02)00245-3",
language = "English",
volume = "41",
pages = "153--162",
journal = "Toxicon",
issn = "0041-0101",
publisher = "Elsevier",
number = "2",
}