Abstrakti
Three different beta-linked divalent mannosides, along with their corresponding monovalent counterparts, have been designed and chemically synthesized by coupling the corresponding propargyl (propargyl alcohol in the case of the monovalent compounds) and 2-azidoethyl glycosides by using an efficient click chemistry protocol. Crich's beta-mannosylation methodology was applied to the construction of the beta-mannosidic linkages. All the glycosylation reactions gave moderate-to-good yields with high selectivities. A competitive inhibition enzyme-linked immunosorbent assay (ELISA) was performed to determine the inhibition, by the synthesized mannosides, of specific human IgG binding to low-molecular-weight Candida albicans mannan; moderate inhibition capacity was observed for some of the compounds.
Alkuperäiskieli | Ei tiedossa |
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Sivut | 2957–2968 |
Sivumäärä | 12 |
Julkaisu | European Journal of Organic Chemistry |
Numero | 15 |
DOI - pysyväislinkit | |
Tila | Julkaistu - 2012 |
OKM-julkaisutyyppi | A1 Julkaistu artikkeli, soviteltu |
Keywords
- Biological activity
- Click chemistry
- Glycosylation
- Medicinal chemistry