Surface plasmon resonance imaging microscopy of liposomes and liposome-encapsulated gold nanoparticles

Lauri Viitala; Adam M. Maley; H. W.Millie Fung; Robert M. Corn; Tapani Viitala; Lasse Murtomäki

doi:10.1021/acs.jpcc.6b09503

Surface plasmon resonance imaging microscopy of liposomes and liposome-encapsulated gold nanoparticles

Lauri Viitala
, Adam M. Maley
, H. W.Millie Fung
, Robert M. Corn
, Tapani Viitala
, Lasse Murtomäki^*

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

18 Sitaatiot (Scopus)

Abstrakti

Liposomes are small vesicles that can be used in various targeting applications as carrier vehicles. In this paper, we show that real-time surface plasmon resonance imaging microscopy (SPRI microscopy) can be used to detect diffraction patterns of these singular vesicles in water phase at room temperature and without any additives. The diffraction pattern intensities, related to the particle size, are shown to follow the log-normal distribution in a cumulative distribution function (CDF) that is very well in accordance with the normal size distribution of liposomes prepared with the extrusion method. In addition, this distribution is further analyzed to determine the number of gold nanoparticle (GNP) encapsulated liposomes in a set of liposomal adsorption events. Thus, we obtain the encapsulation efficiency and present a method to study the intrinsic properties of liposomes and other soft nanomaterials. (Figure Presented).

Alkuperäiskieli	Englanti
Sivut	25958-25966
Sivumäärä	9
Julkaisu	Journal of Physical Chemistry C
Vuosikerta	120
Numero	45
DOI - pysyväislinkit	https://doi.org/10.1021/acs.jpcc.6b09503
Tila	Julkaistu - 17 marrask. 2016
Julkaistu ulkoisesti	Kyllä
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

Rahoitus

The Academy of Finland is acknowledged for funding via the Programmable Materials Program "Light Triggered Nanoparticles" (OMA, #263453). National Science Foundation is acknowledged for the financial support through the Grant CHE-1403506 (RMC). L.V. thanks Mr. Yuhei Terada, Mr. Gerald Manuel, Ms. Kellen Kartub, and Mr. Brandon Matthews for their valuable help and fruitful discussions on the surface preparation techniques and with the SPRI measurements. This paper made use of the UCI laser facility premises run by Dmitry Fishman who is acknowledged for his help with the instruments.

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10.1021/acs.jpcc.6b09503

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title = "Surface plasmon resonance imaging microscopy of liposomes and liposome-encapsulated gold nanoparticles",

abstract = "Liposomes are small vesicles that can be used in various targeting applications as carrier vehicles. In this paper, we show that real-time surface plasmon resonance imaging microscopy (SPRI microscopy) can be used to detect diffraction patterns of these singular vesicles in water phase at room temperature and without any additives. The diffraction pattern intensities, related to the particle size, are shown to follow the log-normal distribution in a cumulative distribution function (CDF) that is very well in accordance with the normal size distribution of liposomes prepared with the extrusion method. In addition, this distribution is further analyzed to determine the number of gold nanoparticle (GNP) encapsulated liposomes in a set of liposomal adsorption events. Thus, we obtain the encapsulation efficiency and present a method to study the intrinsic properties of liposomes and other soft nanomaterials. (Figure Presented).",

author = "Lauri Viitala and Maley, \{Adam M.\} and Fung, \{H. W.Millie\} and Corn, \{Robert M.\} and Tapani Viitala and Lasse Murtom{\"a}ki",

note = "Funding Information: The Academy of Finland is acknowledged for funding via the Programmable Materials Program {"}Light Triggered Nanoparticles{"} (OMA, \#263453). National Science Foundation is acknowledged for the financial support through the Grant CHE-1403506 (RMC). L.V. thanks Mr. Yuhei Terada, Mr. Gerald Manuel, Ms. Kellen Kartub, and Mr. Brandon Matthews for their valuable help and fruitful discussions on the surface preparation techniques and with the SPRI measurements. This paper made use of the UCI laser facility premises run by Dmitry Fishman who is acknowledged for his help with the instruments. Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

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day = "17",

doi = "10.1021/acs.jpcc.6b09503",

language = "English",

volume = "120",

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journal = "Journal of Physical Chemistry C",

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TY - JOUR

T1 - Surface plasmon resonance imaging microscopy of liposomes and liposome-encapsulated gold nanoparticles

AU - Viitala, Lauri

AU - Maley, Adam M.

AU - Fung, H. W.Millie

AU - Corn, Robert M.

AU - Viitala, Tapani

AU - Murtomäki, Lasse

N1 - Funding Information: The Academy of Finland is acknowledged for funding via the Programmable Materials Program "Light Triggered Nanoparticles" (OMA, #263453). National Science Foundation is acknowledged for the financial support through the Grant CHE-1403506 (RMC). L.V. thanks Mr. Yuhei Terada, Mr. Gerald Manuel, Ms. Kellen Kartub, and Mr. Brandon Matthews for their valuable help and fruitful discussions on the surface preparation techniques and with the SPRI measurements. This paper made use of the UCI laser facility premises run by Dmitry Fishman who is acknowledged for his help with the instruments. Publisher Copyright: © 2016 American Chemical Society.

PY - 2016/11/17

Y1 - 2016/11/17

N2 - Liposomes are small vesicles that can be used in various targeting applications as carrier vehicles. In this paper, we show that real-time surface plasmon resonance imaging microscopy (SPRI microscopy) can be used to detect diffraction patterns of these singular vesicles in water phase at room temperature and without any additives. The diffraction pattern intensities, related to the particle size, are shown to follow the log-normal distribution in a cumulative distribution function (CDF) that is very well in accordance with the normal size distribution of liposomes prepared with the extrusion method. In addition, this distribution is further analyzed to determine the number of gold nanoparticle (GNP) encapsulated liposomes in a set of liposomal adsorption events. Thus, we obtain the encapsulation efficiency and present a method to study the intrinsic properties of liposomes and other soft nanomaterials. (Figure Presented).

AB - Liposomes are small vesicles that can be used in various targeting applications as carrier vehicles. In this paper, we show that real-time surface plasmon resonance imaging microscopy (SPRI microscopy) can be used to detect diffraction patterns of these singular vesicles in water phase at room temperature and without any additives. The diffraction pattern intensities, related to the particle size, are shown to follow the log-normal distribution in a cumulative distribution function (CDF) that is very well in accordance with the normal size distribution of liposomes prepared with the extrusion method. In addition, this distribution is further analyzed to determine the number of gold nanoparticle (GNP) encapsulated liposomes in a set of liposomal adsorption events. Thus, we obtain the encapsulation efficiency and present a method to study the intrinsic properties of liposomes and other soft nanomaterials. (Figure Presented).

UR - https://www.scopus.com/pages/publications/85018965712

U2 - 10.1021/acs.jpcc.6b09503

DO - 10.1021/acs.jpcc.6b09503

M3 - Article

AN - SCOPUS:85018965712

SN - 1932-7447

VL - 120

SP - 25958

EP - 25966

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

IS - 45

ER -

Surface plasmon resonance imaging microscopy of liposomes and liposome-encapsulated gold nanoparticles

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