Structural Catalytic Core in Subtilisin-like Proteins and Its Comparison to Trypsin-like Serine Proteases and Alpha/Beta-Hydrolases

Alexandre Denesyuk*, Konstantin Denessiouk, Mark Johnson, Vladimir Uversky*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

3 Lataukset (Pure)

Abstrakti

Subtilisin-like proteins are serine proteases that use two types of catalytic triads: Ser-His-Asp and Ser-Glu-Asp. Here, we investigate the two known families of subtilisin-like proteins, the subtilases (Ser-His-Asp triad) and the serine-carboxyl proteinases (Ser-Glu-Asp triad), and describe the local structural arrangements (cores) that govern the catalytic residues in these proteins. We show the separation of the cores into conserved structural zones, which can be repeatedly found in different structures, and compare the structural cores in subtilisin-like proteins with those in trypsin-like serine proteases and alpha/beta-hydrolases.
AlkuperäiskieliEnglanti
Artikkeli11858
Sivut11858
JulkaisuInternational Journal of Molecular Sciences
Vuosikerta25
Numero22
DOI - pysyväislinkit
TilaJulkaistu - 5 marrask. 2024
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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