[Stress-responsive systems in the rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic "Symbiter"].

K. O. Dvorshchenko*, S. I. Vakal, A. S. Dranytsyna, S. A. Senin, L. I. Ostapchenko

*Tämän työn vastaava kirjoittaja

    Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

    2 Sitaatiot (Scopus)

    Abstrakti

    The intensity of free-radical processes upon long-term omeprazole-induced hypoacidity in the rat pancreas was investigated. Significant violation of oxidative-antioxidative balance in pancreatic tissue upon gastric hypochlorhydria was established: overproduction of superoxide anion, quantitative changes of lipid functional groups, increased level of lipid peroxidation products, augmentation of xanthine oxidase, superoxide dismutase and glutathione transferase activity, as well as depletion of catalase, glutathione peroxidase activity and reduced glutathione content. The inflected expression of Cckbr gene in the rat pancreas upon these conditions was also observed, thus suggesting an increased risk of pathological changes development in the gland. Abovementioned parameters were only partially restored to control values in the case of simultaneous administration of multiprobiotic "Symbiter" with omeprazole, thus indicating the ability of this preparation to efficiently counteract the development of oxidative damages in pancreatic tissues upon long-term hypoacidic conditions.

    AlkuperäiskieliEnglanti
    Sivut68-77
    Sivumäärä10
    JulkaisuThe Ukrainian Biochemical Journal
    Vuosikerta85
    Numero2
    DOI - pysyväislinkit
    TilaJulkaistu - 2013
    OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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