Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan; Haixia Zou; Wenhui Zhou; Xiaowan Yuan; Zhijun Li; Xiaodong Ma; Chang Liu; Yonghui Wang; Jessica M. Rosenholm; Wenguo Cui; Xiangmeng Qu; Hongbo Zhang

doi:10.1039/D2BM00640E

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan
, Haixia Zou
, Wenhui Zhou
, Xiaowan Yuan
, Zhijun Li
, Xiaodong Ma
, Chang Liu
, Yonghui Wang
, Jessica M. Rosenholm
, Wenguo Cui
, Xiangmeng Qu
, Hongbo Zhang^*

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

20 Sitaatiot (Scopus)

94 Lataukset (Pure)

Abstrakti

Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

Alkuperäiskieli	Englanti
Sivut	4119-4125
Sivumäärä	7
Julkaisu	Biomaterials Science
Vuosikerta	10
Numero	15
DOI - pysyväislinkit	https://doi.org/10.1039/D2BM00640E
Tila	Julkaistu - 20 kesäk. 2022
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 3 – Hyvä terveys ja hyvinvointi

Pääsy asiakirjaan

10.1039/D2BM00640ELisenssi: CC BY

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy 2022Lopullinen julkaistu versio, 2,44 MBLisenssi: CC BY

Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Luonnontieteiden ja tekniikan tiedekunta
Laitteistot/tilat: Laitos

2 Päättynyt

FCFH: Finland-China Network in Food and Health Sciences
Rosenholm, J. (Vastuullinen tutkija), Xu, C. (Vastuullinen tutkija) & Zhang, H. (Vastuullinen tutkija)
Opetus- ja kulttuuriministeriö
01/01/21 → 31/12/24
Projekti: Ministry / Government Agency
Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout
Zhang, H. (Vastuullinen tutkija)
01/09/19 → 31/08/24
Projekti: Research Council of Finland/Other Research Councils

Viittausmuodot

@article{8478309e04cd43f4bcb4036a857de134,

title = "Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy",

abstract = "Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.",

author = "Jiaqi Yan and Haixia Zou and Wenhui Zhou and Xiaowan Yuan and Zhijun Li and Xiaodong Ma and Chang Liu and Yonghui Wang and Rosenholm, \{Jessica M.\} and Wenguo Cui and Xiangmeng Qu and Hongbo Zhang",

year = "2022",

month = jun,

day = "20",

doi = "10.1039/D2BM00640E",

language = "English",

volume = "10",

pages = "4119--4125",

journal = "Biomaterials Science",

issn = "2047-4849",

publisher = "Royal Society of Chemistry",

number = "15",

}

TY - JOUR

T1 - Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

AU - Yan, Jiaqi

AU - Zou, Haixia

AU - Zhou, Wenhui

AU - Yuan, Xiaowan

AU - Li, Zhijun

AU - Ma, Xiaodong

AU - Liu, Chang

AU - Wang, Yonghui

AU - Rosenholm, Jessica M.

AU - Cui, Wenguo

AU - Qu, Xiangmeng

AU - Zhang, Hongbo

PY - 2022/6/20

Y1 - 2022/6/20

N2 - Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

AB - Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

U2 - 10.1039/D2BM00640E

DO - 10.1039/D2BM00640E

M3 - Article

SN - 2047-4849

VL - 10

SP - 4119

EP - 4125

JO - Biomaterials Science

JF - Biomaterials Science

IS - 15

ER -

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Abstrakti

YK:n kestävän kehityksen tavoitteet

Pääsy asiakirjaan

Sormenjälki

Laitteet

Åbo Akademi Functional Printing Center

Projektit

FCFH: Finland-China Network in Food and Health Sciences

Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout

Viittausmuodot