Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan; Haixia Zou; Wenhui Zhou; Xiaowan Yuan; Zhijun Li; Xiaodong Ma; Chang Liu; Yonghui Wang; Jessica M. Rosenholm; Wenguo Cui; Xiangmeng Qu; Hongbo Zhang

doi:10.1039/D2BM00640E

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan, Haixia Zou, Wenhui Zhou, Xiaowan Yuan, Zhijun Li, Xiaodong Ma, Chang Liu, Yonghui Wang, Jessica M. Rosenholm, Wenguo Cui, Xiangmeng Qu, Hongbo Zhang^*

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

19 Sitaatiot (Scopus)

32 Lataukset (Pure)

Abstrakti

Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

Alkuperäiskieli	Englanti
Sivut	4119-4125
Sivumäärä	7
Julkaisu	Biomaterials Science
Vuosikerta	10
Numero	15
DOI - pysyväislinkit	https://doi.org/10.1039/D2BM00640E
Tila	Julkaistu - 20 kesäk. 2022
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

Pääsy asiakirjaan

10.1039/D2BM00640ELisenssi: CC BY

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy 2022Lopullinen julkaistu versio, 2,44 MBLisenssi: CC BY

Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Faculty of Science and Engineering
Laitteistot/tilat: Laitos

FCFH: Finland-China Network in Food and Health Sciences
Rosenholm, J. (Vastuullinen tutkija), Xu, C. (Vastuullinen tutkija) & Zhang, H. (Vastuullinen tutkija)
Opetus- ja kulttuuriministeriö
01/01/21 → 31/12/24
Projekti: Ministry / Government Agency
Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout
Zhang, H. (Vastuullinen tutkija)
01/09/19 → 31/08/24
Projekti: Research Council of Finland/Other Research Councils

Viittausmuodot

@article{8478309e04cd43f4bcb4036a857de134,

title = "Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy",

abstract = "Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.",

author = "Jiaqi Yan and Haixia Zou and Wenhui Zhou and Xiaowan Yuan and Zhijun Li and Xiaodong Ma and Chang Liu and Yonghui Wang and Rosenholm, {Jessica M.} and Wenguo Cui and Xiangmeng Qu and Hongbo Zhang",

year = "2022",

month = jun,

day = "20",

doi = "10.1039/D2BM00640E",

language = "English",

volume = "10",

pages = "4119--4125",

journal = "Biomaterials Science",

issn = "2047-4849",

publisher = "Royal Society of Chemistry",

number = "15",

}

TY - JOUR

T1 - Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

AU - Yan, Jiaqi

AU - Zou, Haixia

AU - Zhou, Wenhui

AU - Yuan, Xiaowan

AU - Li, Zhijun

AU - Ma, Xiaodong

AU - Liu, Chang

AU - Wang, Yonghui

AU - Rosenholm, Jessica M.

AU - Cui, Wenguo

AU - Qu, Xiangmeng

AU - Zhang, Hongbo

PY - 2022/6/20

Y1 - 2022/6/20

N2 - Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

AB - Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

U2 - 10.1039/D2BM00640E

DO - 10.1039/D2BM00640E

M3 - Article

SN - 2047-4849

VL - 10

SP - 4119

EP - 4125

JO - Biomaterials Science

JF - Biomaterials Science

IS - 15

ER -

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Abstrakti

YK:n kestävän kehityksen tavoitteet

Pääsy asiakirjaan

Sormenjälki

Laitteet

Åbo Akademi Functional Printing Center

Projektit

FCFH: Finland-China Network in Food and Health Sciences

Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout

Viittausmuodot