Ras nanoclusters: Molecular structure and assembly

Daniel Abankwa, AA Gorfe, JF Hancock

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

99 Sitaatiot (Scopus)

Abstrakti

H-, N- and K-ras4B are lipid-anchored, peripheral membrane guanine nucleotide binding proteins. Recent work has shown that Ras proteins are laterally segregated into non-overlapping, dynamic domains of the plasma membrane called nanoclusters. This lateral segregation is important to specify Ras interactions with membrane-associated proteins, effectors and scaffolding proteins and is critical for Ras signal transduction. Here we review biological, in vitro and structural data that provide insight into the molecular basis of how palmitoylated Ras proteins are anchored to the plasma membrane. We explore possible mechanisms for how the interactions of H-ras with a lipid bilayer may drive nanocluster formation. (C) 2007 Elsevier Ltd. All rights reserved.
AlkuperäiskieliEi tiedossa
Sivut599–607
Sivumäärä9
JulkaisuSeminars in Cell and Developmental Biology
Vuosikerta18
Numero5
DOI - pysyväislinkit
TilaJulkaistu - 2007
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Keywords

  • lipid-raft
  • MD simulations
  • nanocluster
  • Ras
  • structure

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