Prins cyclisation of (–)-isopulegol with benzaldehyde over ZSM-5 based micro-mesoporous catalysts for production of pharmaceuticals

Ekaterina Kholkina, Päivi Mäki-Arvela, Chloe Lozachmeur, Roman Barakov, Nataliya Shcherban, Dmitry Murzin

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

5 Sitaatiot (Scopus)

Abstrakti

Several ZSM-5 derived micro-mesoporous catalysts were investigated in Prins cyclisation of (–)-isopulegol with benzaldehyde acting as a reactant and a solvent for production of heterocyclic oxygen containing 2H-chromene derivatives including the tetrahydropyran structure and exhibiting biological activity. The investigated catalysts were characterized by nitrogen adsorption, ammonia temperature programmed desorption, adsorption-desorption of pyridine and 2,6-di-tert-butylpyridine with Fourier transform infrared spectroscopic control. For the Prins reaction performed at 70 °C, the highest yield of the desired product, equal to 67% at complete conversion of (–)-isopulegol, was obtained over a micro-mesoporous catalyst containing an optimum amount of strong acid sites and mesopores, being 12 fold larger than the size of the desired product.
AlkuperäiskieliEi tiedossa
Sivut1713–1720
Sivumäärä8
JulkaisuChinese Journal of Catalysis
Vuosikerta40
Numero11
DOI - pysyväislinkit
TilaJulkaistu - 2019
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Keywords

  • Prins cyclisation
  • Tetrahydropyran
  • Micro-Mesoporous material

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