Porous SiO2 nanofiber grafted novel bioactive glass–ceramic coating: A structural scaffold for uniform apatite precipitation and oriented cell proliferation on inert implant

Indranee Das, De Goutam, Leena Hupa, Pekka K. Vallittu

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

20 Sitaatiot (Scopus)

Abstrakti

A composite bioactive glass-ceramic coating grafted with porous silica nanofibers was fabricated on inert glass to provide a structural scaffold favoring uniform apatite precipitation and oriented cell proliferation. The coating surfaces were investigated thoroughly before and after immersion in simulated body fluid. In addition, the proliferation behavior of fibroblast cells on the surface was observed for several culture times. The nanofibrous exterior of this composite bioactive coating facilitated homogeneous growth of flake-like carbonated hydroxyapatite layer within a short period of immersion. Moreover, the embedded porous silica nanofibers enhanced hydrophilicity which is required for proper cell adhesion on the surface. The cells proliferated well following a particular orientation on the entire coating by the assistance of nanofibrous scaffold-like structural matrix. This newly engineered composite coating was effective in creating a biological structural matrix favorable for homogeneous precipitation of calcium phosphate, and organized cell growth on the inert glass surface.
AlkuperäiskieliEi tiedossa
Sivut206–214
JulkaisuMaterials Science and Engineering: C
Vuosikerta62
DOI - pysyväislinkit
TilaJulkaistu - 2016
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Keywords

  • bioactive coatings
  • bioactive glass
  • Bioactive glass-ceramic
  • Carbonated hydroxyapatite
  • Cell Proliferation
  • Coating
  • Nanofiber
  • Scaffold

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