Oxidation of MC-LR and -RR with chlorine and potassium permanganate: Toxicity of the reaction products

Eva M. Rodríguez; Juan L. Acero; Lisa Spoof; Jussi Meriluoto

doi:10.1016/j.watres.2007.10.039

Oxidation of MC-LR and -RR with chlorine and potassium permanganate: Toxicity of the reaction products

Eva M. Rodríguez^*
, Juan L. Acero
, Lisa Spoof
, Jussi Meriluoto

^*Tämän työn vastaava kirjoittaja

Laboratoryservices

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

87 Sitaatiot (Scopus)

Abstrakti

Toxin-producing cyanobacteria are abundant in surface waters used as drinking water resources. Microcystins (MC) produced by certain cyanobacteria present acute and chronic toxicity, and their removal in drinking water treatment processes is of increasing concern. Previous studies have demonstrated that chlorine and potassium permanganate are feasible oxidants for the removal of MCs present in drinking water resources, although the oxidation might lead to toxic oxidation products. In this paper, the toxicity of the oxidation products of MC-LR and -RR has been studied using protein phosphatase 1 inhibition assay (PPIA). The HPLC and ELISA analyses correlated with the PPIA results for both toxins. The samples containing the oxidation products were fractionated by HPLC and the toxicity of the fractions was tested with PPIA. The results revealed that protein phosphatase 1 inhibition emerged only from intact MC, while the oxidation products were non-toxic. Similar results were obtained in experiments performed in natural waters: no reaction products or interactions exhibiting protein phosphatase 1 inhibition were detected.

Alkuperäiskieli	Englanti
Sivut	1744-1752
Sivumäärä	9
Julkaisu	Water Research
Vuosikerta	42
Numero	6-7
DOI - pysyväislinkit	https://doi.org/10.1016/j.watres.2007.10.039
Tila	Julkaistu - maalisk. 2008
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

Rahoitus

This work was supported by the European Commission under the Fifth Framework Programme, research project TOXIC (EVK1-CT-2002-00107). Dr Wido Schmidt is acknowledged as project coordinator. JM and LS thank the Academy of Finland, RC for Biosciences and Environment for financial support (decision number 108947).

Pääsy asiakirjaan

10.1016/j.watres.2007.10.039

Muut tiedostot ja linkit

Linkki julkaisuun Scopuksessa

Viittausmuodot

@article{e063b72198a84896869aadebef3cffda,

title = "Oxidation of MC-LR and -RR with chlorine and potassium permanganate: Toxicity of the reaction products",

abstract = "Toxin-producing cyanobacteria are abundant in surface waters used as drinking water resources. Microcystins (MC) produced by certain cyanobacteria present acute and chronic toxicity, and their removal in drinking water treatment processes is of increasing concern. Previous studies have demonstrated that chlorine and potassium permanganate are feasible oxidants for the removal of MCs present in drinking water resources, although the oxidation might lead to toxic oxidation products. In this paper, the toxicity of the oxidation products of MC-LR and -RR has been studied using protein phosphatase 1 inhibition assay (PPIA). The HPLC and ELISA analyses correlated with the PPIA results for both toxins. The samples containing the oxidation products were fractionated by HPLC and the toxicity of the fractions was tested with PPIA. The results revealed that protein phosphatase 1 inhibition emerged only from intact MC, while the oxidation products were non-toxic. Similar results were obtained in experiments performed in natural waters: no reaction products or interactions exhibiting protein phosphatase 1 inhibition were detected.",

keywords = "Byproducts, Chlorination, Microcystins, Permanganate oxidation, PPI, Toxicity",

author = "Rodr{\'i}guez, \{Eva M.\} and Acero, \{Juan L.\} and Lisa Spoof and Jussi Meriluoto",

note = "Funding Information: This work was supported by the European Commission under the Fifth Framework Programme, research project TOXIC (EVK1-CT-2002-00107). Dr Wido Schmidt is acknowledged as project coordinator. JM and LS thank the Academy of Finland, RC for Biosciences and Environment for financial support (decision number 108947). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2008",

month = mar,

doi = "10.1016/j.watres.2007.10.039",

language = "English",

volume = "42",

pages = "1744--1752",

journal = "Water Research",

issn = "0043-1354",

publisher = "Iwa publishing",

number = "6-7",

}

TY - JOUR

T1 - Oxidation of MC-LR and -RR with chlorine and potassium permanganate

T2 - Toxicity of the reaction products

AU - Rodríguez, Eva M.

AU - Acero, Juan L.

AU - Spoof, Lisa

AU - Meriluoto, Jussi

N1 - Funding Information: This work was supported by the European Commission under the Fifth Framework Programme, research project TOXIC (EVK1-CT-2002-00107). Dr Wido Schmidt is acknowledged as project coordinator. JM and LS thank the Academy of Finland, RC for Biosciences and Environment for financial support (decision number 108947). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2008/3

Y1 - 2008/3

N2 - Toxin-producing cyanobacteria are abundant in surface waters used as drinking water resources. Microcystins (MC) produced by certain cyanobacteria present acute and chronic toxicity, and their removal in drinking water treatment processes is of increasing concern. Previous studies have demonstrated that chlorine and potassium permanganate are feasible oxidants for the removal of MCs present in drinking water resources, although the oxidation might lead to toxic oxidation products. In this paper, the toxicity of the oxidation products of MC-LR and -RR has been studied using protein phosphatase 1 inhibition assay (PPIA). The HPLC and ELISA analyses correlated with the PPIA results for both toxins. The samples containing the oxidation products were fractionated by HPLC and the toxicity of the fractions was tested with PPIA. The results revealed that protein phosphatase 1 inhibition emerged only from intact MC, while the oxidation products were non-toxic. Similar results were obtained in experiments performed in natural waters: no reaction products or interactions exhibiting protein phosphatase 1 inhibition were detected.

AB - Toxin-producing cyanobacteria are abundant in surface waters used as drinking water resources. Microcystins (MC) produced by certain cyanobacteria present acute and chronic toxicity, and their removal in drinking water treatment processes is of increasing concern. Previous studies have demonstrated that chlorine and potassium permanganate are feasible oxidants for the removal of MCs present in drinking water resources, although the oxidation might lead to toxic oxidation products. In this paper, the toxicity of the oxidation products of MC-LR and -RR has been studied using protein phosphatase 1 inhibition assay (PPIA). The HPLC and ELISA analyses correlated with the PPIA results for both toxins. The samples containing the oxidation products were fractionated by HPLC and the toxicity of the fractions was tested with PPIA. The results revealed that protein phosphatase 1 inhibition emerged only from intact MC, while the oxidation products were non-toxic. Similar results were obtained in experiments performed in natural waters: no reaction products or interactions exhibiting protein phosphatase 1 inhibition were detected.

KW - Byproducts

KW - Chlorination

KW - Microcystins

KW - Permanganate oxidation

KW - PPI

KW - Toxicity

UR - https://www.scopus.com/pages/publications/40749149599

U2 - 10.1016/j.watres.2007.10.039

DO - 10.1016/j.watres.2007.10.039

M3 - Article

C2 - 18037466

AN - SCOPUS:40749149599

SN - 0043-1354

VL - 42

SP - 1744

EP - 1752

JO - Water Research

JF - Water Research

IS - 6-7

ER -

Oxidation of MC-LR and -RR with chlorine and potassium permanganate: Toxicity of the reaction products

Abstrakti

Rahoitus

Pääsy asiakirjaan

Muut tiedostot ja linkit

Sormenjälki

Viittausmuodot