TY - JOUR
T1 - Orodispersible films: Conception to quality by design
AU - Gupta, Maram Suresh
AU - Kumar, Tegginamath Pramod
AU - Gowda, Devegowda Vishkante
AU - Rosenholm, Jessica M.
PY - 2021/11
Y1 - 2021/11
N2 - Orodispersible films (ODFs) are ultra-thin, stamp-sized, elegant, portable and patient-centric pharmaceutical dosage forms that do not need water to be ingested. They are particularly useful for paediatric and geriatric patient populations with special needs such as dysphagia, Parkinson’s disease, and oral cancer. Accordingly, they hold tremendous potential in gaining patient compliance, convenience and pharmacotherapy. In the present review, conception and evolution of ODFs as a product and its technology are discussed. The review continues by providing overview about the potential of ODFs as carriers for delivering drugs, herbal extracts, probiotics and vaccines. Besides, strategies employed in drug cargo loading, taste masking of bitter drugs and enhancing drug stability are discussed. Finally, the review concludes by providing a brief overview about quality by design (QbD) principles in development of ODFs.
AB - Orodispersible films (ODFs) are ultra-thin, stamp-sized, elegant, portable and patient-centric pharmaceutical dosage forms that do not need water to be ingested. They are particularly useful for paediatric and geriatric patient populations with special needs such as dysphagia, Parkinson’s disease, and oral cancer. Accordingly, they hold tremendous potential in gaining patient compliance, convenience and pharmacotherapy. In the present review, conception and evolution of ODFs as a product and its technology are discussed. The review continues by providing overview about the potential of ODFs as carriers for delivering drugs, herbal extracts, probiotics and vaccines. Besides, strategies employed in drug cargo loading, taste masking of bitter drugs and enhancing drug stability are discussed. Finally, the review concludes by providing a brief overview about quality by design (QbD) principles in development of ODFs.
KW - Patient-centric
KW - Probiotics
KW - Vaccines
KW - Quality by design
KW - ODF
KW - QbD
U2 - https://doi.org/10.1016/j.addr.2021.113983
DO - https://doi.org/10.1016/j.addr.2021.113983
M3 - Review Article or Literature Review
SN - 0169-409X
VL - 178
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
M1 - 113983
ER -