Oral Administration of Multistage Albumin Nanomedicine Depots (MANDs) for Targeted Efficient Alleviation of Chronic Inflammatory Diseases

Fangke Zhang; Yawei Du; Jiancheng Zheng; Zhengwei Cai; Tao Ding; Pengzhen Zhuang; Ding Yang; Fangling Liao; Yu Zhang; Wu Yang; Yafang Xiao; Weiling He; Wenguo Cui; Weisheng Guo

doi:10.1002/adfm.202211644

Oral Administration of Multistage Albumin Nanomedicine Depots (MANDs) for Targeted Efficient Alleviation of Chronic Inflammatory Diseases

Fangke Zhang
, Yawei Du
, Jiancheng Zheng
, Zhengwei Cai
, Tao Ding
, Pengzhen Zhuang
, Ding Yang
, Fangling Liao
, Yu Zhang
, Wu Yang
, Yafang Xiao
, Weiling He^*
, Wenguo Cui^*
, Weisheng Guo^*

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

37 Sitaatiot (Scopus)

Abstrakti

Methotrexate (MTX) by oral taking has been employed as the first-line medication for various chronic inflammatory diseases treatment, such as Crohn's disease and rheumatoid arthritis (RA). However, the oral administration of MTX has very limited clinical benefits and will be discontinued due to the suboptimal response and severe adverse effects on intestinal mucosa. Herein, a multistage albumin nanomedicine depot (denoted as MAND) is formulated by encapsulating MTX-loaded human serum albumin nanoparticles (MTX@HSA NPs) into calcium alginate chitosan microcapsules using a gas-shearing technology. The MANDs can provide protection to MTX@HSA NPs with well-persisted biologic activity against gastric acid erosion and realize specific boost release of MTX@HSA NPs in the intestinal tract in response to the mild basic circumstance. The MTX@HSA NPs absorbed by intestine can selectively accumulate in inflammation lesion by exploiting the inflammation targeting ability of HSA. In the animal experiments, the MANDs show improved therapeutic efficacy for the treatment of both RA and colitis with minimized intestinal side effects in respect to the free MTX by oral administration. Therefore, this conceived oral MANDs can promote a more clinic popularity and enhanced benefits of MTX for the treatment of chronic inflammatory diseases.

Alkuperäiskieli	Englanti
Artikkeli	2211644
Sivumäärä	14
Julkaisu	Advanced Functional Materials
Vuosikerta	33
Numero	9
DOI - pysyväislinkit	https://doi.org/10.1002/adfm.202211644
Tila	Julkaistu - 23 helmik. 2023
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

Rahoitus

F.Z. and Y.D. contributed equally to this work. The authors thank to Peng Zhang and Wenxiang Chen from Shenzhen Institutes of Advanced Technology (SIAT, CAS) for MH7A cells. This work was supported by grants from National Natural Science Foundation of China (31971302, 22105127, 81871994, 82022037), National Key Research and Development Program of China (2020YFA0908200), Natural Science Foundation of Guangdong Province of China (2019A1515011597, 2019B151502063), the Talent Young Scientist Supporting Program of China Association for Science and Technology, the Educational Commission of Guangdong Province of China key Project (2020ZDZX2001), Guangdong Basic and Applied Basic Research Foundation (2021B1515230009), the joint grant between Guangzhou City and College (202102010106), and Shanghai Pujiang Program (21PJD045). F.Z. and Y.D. contributed equally to this work. The authors thank to Peng Zhang and Wenxiang Chen from Shenzhen Institutes of Advanced Technology (SIAT, CAS) for MH7A cells. This work was supported by grants from National Natural Science Foundation of China (31971302, 22105127, 81871994, 82022037), National Key Research and Development Program of China (2020YFA0908200), Natural Science Foundation of Guangdong Province of China (2019A1515011597, 2019B151502063), the Talent Young Scientist Supporting Program of China Association for Science and Technology, the Educational Commission of Guangdong Province of China key Project (2020ZDZX2001), Guangdong Basic and Applied Basic Research Foundation (2021B1515230009), the joint grant between Guangzhou City and College (202102010106), and Shanghai Pujiang Program (21PJD045).

Pääsy asiakirjaan

10.1002/adfm.202211644

Muut tiedostot ja linkit

Linkki julkaisuun Scopuksessa

Viittausmuodot

Zhang, F., Du, Y., Zheng, J., Cai, Z., Ding, T., Zhuang, P., Yang, D., Liao, F., Zhang, Y., Yang, W., Xiao, Y., He, W., Cui, W., & Guo, W. (2023). Oral Administration of Multistage Albumin Nanomedicine Depots (MANDs) for Targeted Efficient Alleviation of Chronic Inflammatory Diseases. Advanced Functional Materials, 33(9), Artikkeli 2211644. https://doi.org/10.1002/adfm.202211644

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title = "Oral Administration of Multistage Albumin Nanomedicine Depots (MANDs) for Targeted Efficient Alleviation of Chronic Inflammatory Diseases",

abstract = "Methotrexate (MTX) by oral taking has been employed as the first-line medication for various chronic inflammatory diseases treatment, such as Crohn's disease and rheumatoid arthritis (RA). However, the oral administration of MTX has very limited clinical benefits and will be discontinued due to the suboptimal response and severe adverse effects on intestinal mucosa. Herein, a multistage albumin nanomedicine depot (denoted as MAND) is formulated by encapsulating MTX-loaded human serum albumin nanoparticles (MTX@HSA NPs) into calcium alginate chitosan microcapsules using a gas-shearing technology. The MANDs can provide protection to MTX@HSA NPs with well-persisted biologic activity against gastric acid erosion and realize specific boost release of MTX@HSA NPs in the intestinal tract in response to the mild basic circumstance. The MTX@HSA NPs absorbed by intestine can selectively accumulate in inflammation lesion by exploiting the inflammation targeting ability of HSA. In the animal experiments, the MANDs show improved therapeutic efficacy for the treatment of both RA and colitis with minimized intestinal side effects in respect to the free MTX by oral administration. Therefore, this conceived oral MANDs can promote a more clinic popularity and enhanced benefits of MTX for the treatment of chronic inflammatory diseases.",

keywords = "human serum albumin nanomedicines, hydrogel microcapsules, methotrexate, oral administration, rheumatoid arthritis",

author = "Fangke Zhang and Yawei Du and Jiancheng Zheng and Zhengwei Cai and Tao Ding and Pengzhen Zhuang and Ding Yang and Fangling Liao and Yu Zhang and Wu Yang and Yafang Xiao and Weiling He and Wenguo Cui and Weisheng Guo",

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year = "2023",

month = feb,

day = "23",

doi = "10.1002/adfm.202211644",

language = "English",

volume = "33",

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issn = "1616-301X",

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Zhang, F, Du, Y, Zheng, J, Cai, Z, Ding, T, Zhuang, P, Yang, D, Liao, F, Zhang, Y , Yang, W, Xiao, Y, He, W, Cui, W & Guo, W 2023, 'Oral Administration of Multistage Albumin Nanomedicine Depots (MANDs) for Targeted Efficient Alleviation of Chronic Inflammatory Diseases', Advanced Functional Materials, Vuosikerta 33, Nro 9, 2211644. https://doi.org/10.1002/adfm.202211644

TY - JOUR

T1 - Oral Administration of Multistage Albumin Nanomedicine Depots (MANDs) for Targeted Efficient Alleviation of Chronic Inflammatory Diseases

AU - Zhang, Fangke

AU - Du, Yawei

AU - Zheng, Jiancheng

AU - Cai, Zhengwei

AU - Ding, Tao

AU - Zhuang, Pengzhen

AU - Yang, Ding

AU - Liao, Fangling

AU - Zhang, Yu

AU - Yang, Wu

AU - Xiao, Yafang

AU - He, Weiling

AU - Cui, Wenguo

AU - Guo, Weisheng

PY - 2023/2/23

Y1 - 2023/2/23

N2 - Methotrexate (MTX) by oral taking has been employed as the first-line medication for various chronic inflammatory diseases treatment, such as Crohn's disease and rheumatoid arthritis (RA). However, the oral administration of MTX has very limited clinical benefits and will be discontinued due to the suboptimal response and severe adverse effects on intestinal mucosa. Herein, a multistage albumin nanomedicine depot (denoted as MAND) is formulated by encapsulating MTX-loaded human serum albumin nanoparticles (MTX@HSA NPs) into calcium alginate chitosan microcapsules using a gas-shearing technology. The MANDs can provide protection to MTX@HSA NPs with well-persisted biologic activity against gastric acid erosion and realize specific boost release of MTX@HSA NPs in the intestinal tract in response to the mild basic circumstance. The MTX@HSA NPs absorbed by intestine can selectively accumulate in inflammation lesion by exploiting the inflammation targeting ability of HSA. In the animal experiments, the MANDs show improved therapeutic efficacy for the treatment of both RA and colitis with minimized intestinal side effects in respect to the free MTX by oral administration. Therefore, this conceived oral MANDs can promote a more clinic popularity and enhanced benefits of MTX for the treatment of chronic inflammatory diseases.

AB - Methotrexate (MTX) by oral taking has been employed as the first-line medication for various chronic inflammatory diseases treatment, such as Crohn's disease and rheumatoid arthritis (RA). However, the oral administration of MTX has very limited clinical benefits and will be discontinued due to the suboptimal response and severe adverse effects on intestinal mucosa. Herein, a multistage albumin nanomedicine depot (denoted as MAND) is formulated by encapsulating MTX-loaded human serum albumin nanoparticles (MTX@HSA NPs) into calcium alginate chitosan microcapsules using a gas-shearing technology. The MANDs can provide protection to MTX@HSA NPs with well-persisted biologic activity against gastric acid erosion and realize specific boost release of MTX@HSA NPs in the intestinal tract in response to the mild basic circumstance. The MTX@HSA NPs absorbed by intestine can selectively accumulate in inflammation lesion by exploiting the inflammation targeting ability of HSA. In the animal experiments, the MANDs show improved therapeutic efficacy for the treatment of both RA and colitis with minimized intestinal side effects in respect to the free MTX by oral administration. Therefore, this conceived oral MANDs can promote a more clinic popularity and enhanced benefits of MTX for the treatment of chronic inflammatory diseases.

KW - human serum albumin nanomedicines

KW - hydrogel microcapsules

KW - methotrexate

KW - oral administration

KW - rheumatoid arthritis

UR - https://www.scopus.com/pages/publications/85146310346

U2 - 10.1002/adfm.202211644

DO - 10.1002/adfm.202211644

M3 - Article

AN - SCOPUS:85146310346

SN - 1616-301X

VL - 33

JO - Advanced Functional Materials

JF - Advanced Functional Materials

IS - 9

M1 - 2211644

ER -

Oral Administration of Multistage Albumin Nanomedicine Depots (MANDs) for Targeted Efficient Alleviation of Chronic Inflammatory Diseases

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