Norway spruce galactoglucomannans exhibiting immunomodulating and radical-scavenging activities.

Ebringerová, Hromádková, Hríbalová, Xu, Bjarne Holmbom, Anna Sundberg, Stefan Willför

    Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

    45 Sitaatiot (Scopus)


    Wood-derived naturally acetylated galactoglucomannans (AcGGM) can be recovered even in ton-scale at mechanical pulp mills using spruce as raw material. These cell wall polysaccharides have a great potential as hydrocolloids and bioactive polymers in food and pharmaceutical applications, or as starting material for production of functional polymers. The immunostimulatory activity of both AcGGM and its deacetylated form (GGM) was now in vitro tested. The biological response of both AcGGM and GGM in the lymphocyte transformation test was dose-dependent. The direct mitogenic as well as comitogenic activities of the AcGGM were comparable to those of the immunogenic corn cob xylan used as control, and GGM showed significantly higher biological responses also at lower doses. In contrast to GGM, AcGGM possessed also DPPH radical-scavenging activity. The results suggested that the spruce AcGGM and GGM are potentially important as additives with immuno-potentiating and antioxidant properties in food products and pharmaceutical formulations.
    AlkuperäiskieliEi tiedossa
    JulkaisuInternational Journal of Biological Macromolecules
    DOI - pysyväislinkit
    TilaJulkaistu - 2008
    OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu


    • Spruce wood
    • galactoglucomannans (GGM)
    • free radical scavenging activity
    • mitogenic and comitogenic activity