New nucleoside analogs from 2-amino-9-(β-D-ribofuranosyl)purine

P Virta, T Holmström, MU Roslund, Peter Mattjus, Leif Kronberg, R Sjöholm

    Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

    9 Sitaatiot (Scopus)

    Abstrakti

    Four novel derivatives of 2-amino-9-(beta-D-ribofuranosyl) purine ( 1) were synthesised and fully characterised. When 1 was reacted with chloroacetaldehyde (a), 2-chloropropanal (b), bromomalonaldehyde (c) and a mixture of chloroacetaldehyde + malonaldehyde (d), 3-(beta-D-ribofuranosyl)- imidazo-[1,2a] purine (2), 3-(beta-D-ribofuranosyl)-5- methylimidazo-[1,2a] purine (3), 3-(beta-D-ribofuranosyl)-5-formylimidazo-[1,2a] purine (4) and 9-(beta-D-ribofuranosyl)-2-( 3,5-diformyl-4-methyl-1,4-dihydro-1-pyridyl) purine (5) were formed, respectively. The products were isolated, purified by chromatography and characterised by MS, complete NMR assignment as well as fluorescence and UV spectroscopy. The yields of these reactions were moderate ( 14 - 20%). The fluorescence properties differed from those of the starting compound and the quantum yields were considerably lower.
    AlkuperäiskieliEi tiedossa
    Sivut821–827
    Sivumäärä7
    JulkaisuOrganic and Biomolecular Chemistry
    Vuosikerta2
    Numero6
    DOI - pysyväislinkit
    TilaJulkaistu - 2004
    OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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