Network analytics for drug repurposing in COVID-19

Nicoleta Siminea, Victor Popescu, Jose Angel Sanchez Martin, Daniela Florea, Georgiana Gavril, Ana-Maria Gheorghe, Corina Iţcuş, Krishna Kanhaiya, Octavian Pacioglu, Laura Ioana Popa, Romica Trandafir, Maria Iris Tusa, Manuela Sidoroff, Mihaela Pãun, Eugen Czeizler, Andrei Pãun, Ion Petre*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

16 Sitaatiot (Scopus)
17 Lataukset (Pure)

Abstrakti

To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins and directed PPI data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.

AlkuperäiskieliEnglanti
Artikkelibbab490
JulkaisuBriefings in Bioinformatics
Vuosikerta23
Numero1
DOI - pysyväislinkit
TilaJulkaistu - 1 tammik. 2022
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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