Modeling of a hybrid Langmuir adsorption isotherm for describing interactions between drug molecules and silica surfaces

Thomas Sandberg, Christian Weinberger, Didem Sen Karaman, Jessica Rosenholm

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

6 Sitaatiot (Scopus)
6 Lataukset (Pure)

Abstrakti

The interaction between disulfiram (Antabus®) and silica was studied experimentally by adsorption from apolar solvent onto highly porous silica material (Santa Barbara Amorphous material-3, SBA-3) with large surface area. The adsorption isotherm was fitted to the Langmuir model by accounting two different affinities contributing to the overall behavior, which were attributed to two different types of silanol groups (i.e. geminal and vicinal) present on amorphous silica surfaces. This assumption was supported by theoretical calculations. Additionally, the model could describe the adsorption of ibuprofen to the carrier material, indicating that the model bears big potential for describing the interactions between silica surfaces and drug molecules.

AlkuperäiskieliEi tiedossa
Sivut1392–1397
JulkaisuJournal of Pharmaceutical Sciences
Vuosikerta107
Numero5
DOI - pysyväislinkit
TilaJulkaistu - 2018
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Keywords

  • Ab initio calculations
  • Adsorption
  • Silica

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