Mesoporous silica material TUD-1 as a drug delivery system

T. Heikkilä, J. Salonen, J. Tuura, M. S. Hamdy, G. Mul, N. Kumar, T. Salmi, D. Yu. Murzin, L. Laitinen, A. M. Kaukonen, J. Hirvonen, V.-P. Lehto*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

180 Sitaatiot (Scopus)

Abstrakti

For the first time the feasibility of siliceous mesoporous material TUD-1 (Technische Universiteit Delft) for drug delivery was studied. Model drug, ibuprofen, was adsorbed into TUD-1 mesopores via a soaking procedure. Characterizations with nitrogen adsorption, XRD, TG, HPLC and DSC demonstrated the successful inclusion of ibuprofen into TUD-1 host. The amount of ibuprofen adsorbed into the nanoreservoir of TUD-1 material was higher than reported for other mesoporous silica drug carriers (drug/carrier 49.5 wt.%). Drug release studies in vitro (HBSS buffer pH 5.5) demonstrated a fast and unrestricted liberation of ibuprofen, with 96% released at 210 min of the dissolution assay. The drug dissolution profile of TUD-1 material with the random, foam-like three-dimensional mesopore network and high accessibility to the dissolution medium was found to be much faster (kinetic constant k = 10.7) and more diffusion based (release constant n = 0.64) compared to a mesoporous MCM-41 material with smaller, unidirectional mesopore channels (k = 4.7, n = 0.71). Also, the mesoporous carriers were found to significantly increase the dissolution rate of ibuprofen, when compared to the pure crystalline form of the drug (k = 0.6, n = 0.96). TUD-1 was constituted as a potential drug delivery device with fast release property, with prospective applications in the formulation of poorly soluble drug compounds.

AlkuperäiskieliEnglanti
Sivut133-138
Sivumäärä6
JulkaisuInternational Journal of Pharmaceutics
Vuosikerta331
Numero1
DOI - pysyväislinkit
TilaJulkaistu - 22 helmikuuta 2007
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Sormenjälki

Sukella tutkimusaiheisiin 'Mesoporous silica material TUD-1 as a drug delivery system'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.

Viittausmuodot