Mass spectrometric detection and quantification of nodularin-R in flounder livers

Krister Karlsson; Vesa Sipiä; Eberhard Krause; Jussi Meriluoto; Stephan Pflugmacher

doi:10.1002/tox.10126

Mass spectrometric detection and quantification of nodularin-R in flounder livers

Krister Karlsson^*, Vesa Sipiä, Eberhard Krause, Jussi Meriluoto, Stephan Pflugmacher

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

23 Sitaatiot (Scopus)

Abstrakti

Livers of flounders caught during August 1995 from the western Gulf of Finland and the Archipelago Sea were analyzed for nodularin-R (NODLN) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography-electrospray ionization-mass spectrometry (LC-MS). Results showed that NODLN was detected in samples by both MS techniques. NODLN content in samples varied between 0.082 and 0.637 μg g^-1 wet weight by LC-MS. Biotransformation products such as glutathione adduct were not found in the samples. The results showed that intact NODLN can be found in tissues after storage at -70°C for several years.

Alkuperäiskieli	Englanti
Sivut	284-288
Sivumäärä	5
Julkaisu	Environmental Toxicology
Vuosikerta	18
Numero	5
DOI - pysyväislinkit	https://doi.org/10.1002/tox.10126
Tila	Julkaistu - 2003
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

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10.1002/tox.10126

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@article{a8c545a4338546fa98ec248cbcf52a17,

title = "Mass spectrometric detection and quantification of nodularin-R in flounder livers",

abstract = "Livers of flounders caught during August 1995 from the western Gulf of Finland and the Archipelago Sea were analyzed for nodularin-R (NODLN) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography-electrospray ionization-mass spectrometry (LC-MS). Results showed that NODLN was detected in samples by both MS techniques. NODLN content in samples varied between 0.082 and 0.637 μg g-1 wet weight by LC-MS. Biotransformation products such as glutathione adduct were not found in the samples. The results showed that intact NODLN can be found in tissues after storage at -70°C for several years.",

keywords = "Baltic Sea, Flounder, Liver, Mass spectrometry, Nodularin",

author = "Krister Karlsson and Vesa Sipi{\"a} and Eberhard Krause and Jussi Meriluoto and Stephan Pflugmacher",

year = "2003",

doi = "10.1002/tox.10126",

language = "English",

volume = "18",

pages = "284--288",

journal = "Environmental Toxicology",

issn = "1520-4081",

publisher = "Wiley",

number = "5",

}

TY - JOUR

T1 - Mass spectrometric detection and quantification of nodularin-R in flounder livers

AU - Karlsson, Krister

AU - Sipiä, Vesa

AU - Krause, Eberhard

AU - Meriluoto, Jussi

AU - Pflugmacher, Stephan

PY - 2003

Y1 - 2003

N2 - Livers of flounders caught during August 1995 from the western Gulf of Finland and the Archipelago Sea were analyzed for nodularin-R (NODLN) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography-electrospray ionization-mass spectrometry (LC-MS). Results showed that NODLN was detected in samples by both MS techniques. NODLN content in samples varied between 0.082 and 0.637 μg g-1 wet weight by LC-MS. Biotransformation products such as glutathione adduct were not found in the samples. The results showed that intact NODLN can be found in tissues after storage at -70°C for several years.

AB - Livers of flounders caught during August 1995 from the western Gulf of Finland and the Archipelago Sea were analyzed for nodularin-R (NODLN) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography-electrospray ionization-mass spectrometry (LC-MS). Results showed that NODLN was detected in samples by both MS techniques. NODLN content in samples varied between 0.082 and 0.637 μg g-1 wet weight by LC-MS. Biotransformation products such as glutathione adduct were not found in the samples. The results showed that intact NODLN can be found in tissues after storage at -70°C for several years.

KW - Baltic Sea

KW - Flounder

KW - Liver

KW - Mass spectrometry

KW - Nodularin

UR - http://www.scopus.com/inward/record.url?scp=0141927366&partnerID=8YFLogxK

U2 - 10.1002/tox.10126

DO - 10.1002/tox.10126

M3 - Article

C2 - 14502579

AN - SCOPUS:0141927366

SN - 1520-4081

VL - 18

SP - 284

EP - 288

JO - Environmental Toxicology

JF - Environmental Toxicology

IS - 5

ER -

Mass spectrometric detection and quantification of nodularin-R in flounder livers

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