TY - GEN
T1 - Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers
AU - Sarcina, Lucia
AU - Viola, Fabrizio
AU - Modena, Francesco
AU - Bollella, Paolo
AU - Caironi, Mario
AU - Esposito, Irene
AU - Torsi, Luisa
AU - Torricelli, Fabrizio
AU - MacChia, Eleonora
N1 - BOF 15/1 EK
Funding Information:
ACKNOWLEDGMENT The projects: SiMBiT—Single molecule bioelectronic smart system array for clinical testing (Grant Agreement ID: 824946), Dottorati innovativi con caratterizzazione industrial—PON R&I 2014–2020 “Sensore bio-elettronico usa-e-getta per l’HIV autoalimentato da una cella a combustibile biologica”, Academy of Finland #332106 “ProSiT—Protein Detection at the Single-Molecule Limit with a Self-powered Organic Transistor for HIV early diagnosis,”, Biosensori analitici usa-e getta a base di transistori organici auto-alimentati per la rivelazione di biomarcatori proteomici alla singola molecola per la diagnostica decentrata dell’HIV (6CDD3786); Research for Innovation REFIN—Regione Puglia POR PUGLIA FESR-FSE 2014/2020, “GREENELIT” under the EU H2020 research and innovation programme - Twinning of research institutions (Grant agreement ID: 951747), Åbo Akademi University CoE “Bioelectronic activation of cell functions” and CSGI are acknowledged for partial financial support. The fabrication of the EG-OFETs was partially carried out at PoliFab, the micro and nano-technology center of the Politecnico di Milano.
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Pancreatic-biliary cancer represents a challenge for clinicians since the detection is performed at later stages and treated with palliative approaches. A screening method for the early detection should be of paramount importance. The aim of this study is the detection of pancreatic mucinous cysts protein markers (MUC1) in human serum down to the physical limit, using an Electrolyte-gated FET based technology, namely the "Single-Molecule assay with a large Transistor"(SiMoT) platform. The structure and transistor components have been developed on plastic substrates. The 3D gate structure is compatible with an ELISA plate. The functionalization procedure is assessed independently through Surface Plasmon Resonance, enabling the real-time monitoring of the gold modification with antibodies essential for the assay.
AB - Pancreatic-biliary cancer represents a challenge for clinicians since the detection is performed at later stages and treated with palliative approaches. A screening method for the early detection should be of paramount importance. The aim of this study is the detection of pancreatic mucinous cysts protein markers (MUC1) in human serum down to the physical limit, using an Electrolyte-gated FET based technology, namely the "Single-Molecule assay with a large Transistor"(SiMoT) platform. The structure and transistor components have been developed on plastic substrates. The 3D gate structure is compatible with an ELISA plate. The functionalization procedure is assessed independently through Surface Plasmon Resonance, enabling the real-time monitoring of the gold modification with antibodies essential for the assay.
KW - 3D printing
KW - biosensors
KW - single-molecule
KW - SPR
UR - http://www.scopus.com/inward/record.url?scp=85137170763&partnerID=8YFLogxK
U2 - 10.1109/FLEPS53764.2022.9781550
DO - 10.1109/FLEPS53764.2022.9781550
M3 - Conference contribution
AN - SCOPUS:85137170763
T3 - FLEPS 2022 - IEEE International Conference on Flexible and Printable Sensors and Systems, Proceedings
BT - 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS)
PB - the Institute of Electrical and Electronics Engineers, Inc.
T2 - 2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022
Y2 - 10 July 2022 through 13 July 2022
ER -