Intermediate filaments as signaling platforms

Pallari, John Eriksson

    Tutkimustuotos: LehtiartikkeliKatsausartikkelivertaisarvioitu

    78 Sitaatiot (Scopus)

    Abstrakti

    Intermediate filaments (IFs) are cytoskeletal structures that are crucial for maintaining the structural and mechanical integrity of cells and tissues. Intriguingly, a wide range of previously unknown nonmechanical roles for the IF cytoskeleton are emerging: Recent studies have linked IFs to the integration of signals related to the determination of cell size, the regulation of cell migration and cell survival, and the buffering of the effects of stress-activated kinases. The characteristic structural features and expression patterns of the different members of this diverse family of highly abundant proteins make them well suited to act as cell- and tissue-specific modifiers and organizers of signaling.
    AlkuperäiskieliEi tiedossa
    Sivut
    JulkaisuScience's STKE : signal transduction knowledge environment
    Numero366
    DOI - pysyväislinkit
    TilaJulkaistu - 2006
    OKM-julkaisutyyppiA2 Arvio tiedejulkaisuussa (artikkeli)

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