In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats

Francisco R. López-Picón, Anna K. Kirjavainen, Sarita Forsback, Jatta S. Takkinen, Dan Peters, Merja Haaparanta-Solin, Olof Solin

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

6 Sitaatiot (Scopus)

Abstrakti

Norepinephrine modulates cognitive processes such as working and episodic memory. Pathological changes in norepinephrine and norepinephrine transporter (NET) function and degeneration of the locus coeruleus produce irreversible impairments within the whole norepinephrine system, disrupting cognitive processes. Monitoring these changes could enhance diagnostic accuracy and support development of novel therapeutic components for several neurodegenerative diseases. Thus, we aimed to develop a straightforward nucleophilic fluorination method with high molar activity for the novel NET radiotracer [18F]NS12137 and to demonstrate the ability of [18F]NS12137 to quantify changes in NET expression.

AlkuperäiskieliEi tiedossa
Sivut11–19
JulkaisuTheranostics
Vuosikerta9
Numero1
DOI - pysyväislinkit
TilaJulkaistu - 2019
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Viittausmuodot