Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.

A Tornio; AM Filppula; O Kailari; M Neuvonen; TH Nyrönen; T Tapaninen; PJ Neuvonen; Mikko Niemi; JT Backman

doi:10.1038/clpt.2014.141

Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.

A Tornio, AM Filppula, O Kailari, M Neuvonen, TH Nyrönen, T Tapaninen, PJ Neuvonen, Mikko Niemi, JT Backman

Pharmacy

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

115 Sitaatiot (Scopus)

Alkuperäiskieli	Englanti
Julkaisu	Clinical Pharmacology and Therapeutics
DOI - pysyväislinkit	https://doi.org/10.1038/clpt.2014.141
Tila	Julkaistu - lokak. 2014
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

Pääsy asiakirjaan

10.1038/clpt.2014.141

Muut tiedostot ja linkit

http://europepmc.org/abstract/med/24971633

Viittausmuodot

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title = "Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.",

author = "A Tornio and AM Filppula and O Kailari and M Neuvonen and TH Nyr{\"o}nen and T Tapaninen and PJ Neuvonen and Mikko Niemi and JT Backman",

year = "2014",

month = oct,

doi = "10.1038/clpt.2014.141",

language = "English",

journal = "Clinical Pharmacology and Therapeutics",

issn = "0009-9236",

publisher = "American Society for Clinical Pharmacology and Therapeutics",

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TY - JOUR

T1 - Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.

AU - Tornio, A

AU - Filppula, AM

AU - Kailari, O

AU - Neuvonen, M

AU - Nyrönen, TH

AU - Tapaninen, T

AU - Neuvonen, PJ

AU - Niemi, Mikko

AU - Backman, JT

PY - 2014/10

Y1 - 2014/10

UR - http://europepmc.org/abstract/med/24971633

U2 - 10.1038/clpt.2014.141

DO - 10.1038/clpt.2014.141

M3 - Article

C2 - 24971633

SN - 0009-9236

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

ER -