Enterprise education is a policy-driven, cross-curricular phenomenon on many Western countries’ educational agendas. The expectation is that it will be implemented in different school subjects, but bridging enterprise education and different school subjects has proven to be a challenge. This article explores whether and how open-ended investigations in science education in secondary schools can be viewed as a form of enterprise education. We identify several points of contact, illuminating the premises on which enterprise education can be integrated into science education. Thus, the results contribute to the underresearched field of bridging enterprise education with school subjects in secondary education.