Excitation functions for proton-induced reactions on natural hafnium: Production of Lu-177 for medical use

T. Siiskonen, J. Huikari, T. Haavisto, J. Bergman, S-J Heselius, Jan-Olof Lill, T. Lönnroth, K. Peräjärvi, V-P Vartti

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    Abstrakti

    There is an increasing interest in using radioisotopes of rare earth elements for internal radiotherapy and for imaging in nuclear medicine. Lu-177 is one of the promising radionuclides. This article reports on the first measurements of the excitation function for the production of Lu-177 with proton-beam energies up to 17 MeV on natural hafnium targets. The experimental cross sections for the reaction Hf-nat(p,x), Lu-177 were obtained by the activation of a stacked-foil target and subsequent gamma spectrometry. Theoretical cross sections were calculated up to 35 MeV with the EMPIRE nuclear reaction model code. The measured and calculated cross sections were used for deriving the thick-target yields and for estimating the production of other nuclides than Lu-177. Measured production cross sections of Ta-175,Ta-176,Ta-177,Ta-178 on the same target are also presented. (C) 2009 Elsevier B.V. All rights reserved.
    AlkuperäiskieliEi tiedossa
    Sivut3500–3504
    Sivumäärä5
    JulkaisuNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
    Vuosikerta267
    Numero21-22
    DOI - pysyväislinkit
    TilaJulkaistu - 2009
    OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

    Keywords

    • Cross sections
    • Hf target
    • Lu-177
    • Medical isotopes
    • Proton-induced reactions

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