TY - JOUR
T1 - Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy
AU - Tuominen, Sanni
AU - Keller, Thomas
AU - Petruk, Natalia
AU - López-Picón, Francisco
AU - Eichin, Dominik
AU - Löyttyniemi, Eliisa
AU - Verhassel , Alejandra
AU - Rajander, Johan
AU - Sandholm , Jouko
AU - Tuomela, Johanna
AU - Grönroos, Tove J
PY - 2020/12/19
Y1 - 2020/12/19
N2 - Many malignant tumours have increased TSPO expression, which has been related to a poor prognosis. TSPO-PET tracers have not comprehensively been evaluated in peripherally located tumours. This study aimed to evaluate whether N,N-diethyl-2-(2-(4-([18F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([18F]F-DPA) can reflect radiotherapy (RT)-induced changes in TSPO activity in head and neck squamous cell carcinoma (HNSCC).
AB - Many malignant tumours have increased TSPO expression, which has been related to a poor prognosis. TSPO-PET tracers have not comprehensively been evaluated in peripherally located tumours. This study aimed to evaluate whether N,N-diethyl-2-(2-(4-([18F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([18F]F-DPA) can reflect radiotherapy (RT)-induced changes in TSPO activity in head and neck squamous cell carcinoma (HNSCC).
KW - Head and neck cancer
KW - PET
KW - Radiotherapy
KW - TSPO
KW - [F-18]F-DPA
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=aboakademi&SrcAuth=WosAPI&KeyUT=WOS:000600095200001&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1007/s00259-020-05115-z
DO - 10.1007/s00259-020-05115-z
M3 - Article
C2 - 33340054
SN - 1619-7070
VL - 48
SP - 1312
EP - 1326
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
IS - 5
ER -