Enzyme based field effect transistor: State-of-the-art and future perspectives

Lucia Sarcina; Eleonora Macchia; Angelo Tricase; Cecilia Scandurra; Anna Imbriano; Fabrizio Torricelli; Nicola Cioffi; Luisa Torsi; Paolo Bollella

doi:10.1002/elsa.202100216

Enzyme based field effect transistor: State-of-the-art and future perspectives

Lucia Sarcina
, Eleonora Macchia
, Angelo Tricase
, Cecilia Scandurra
, Anna Imbriano
, Fabrizio Torricelli
, Nicola Cioffi
, Luisa Torsi^*
, Paolo Bollella^*

^*Tämän työn vastaava kirjoittaja

Fysiikka

Tutkimustuotos: Lehtiartikkeli › Lyhyt tutkimus › vertaisarvioitu

24 Sitaatiot (Scopus)

85 Lataukset (Pure)

Abstrakti

The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices’ configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.

Alkuperäiskieli	Englanti
Artikkeli	e2100216
Julkaisu	Electrochemical Science Advances
Vuosikerta	3
Numero	3
DOI - pysyväislinkit	https://doi.org/10.1002/elsa.202100216
Tila	Julkaistu - kesäk. 2023
OKM-julkaisutyyppi	O2 Other

Rahoitus

Lucia Sarcina and Eleonora Macchia contributed equally to this work. The following funding agencies are acknowledged: Academy of Finland projects #316881, #316883 ‘‘Spatiotemporal control of Cell Functions’’, #332106 “ProSiT—Protein Detection at the Single‐Molecule Limit with a Self‐powered Organic Transistor for HIV early diagnosis”; Biosensori analitici usa‐e getta a base di transistori organici auto‐alimentati per la rivelazione di biomarcatori proteomici alla singola molecola per la diagnostica decentrata dell'HIV (6CDD3786); Research for Innovation REFIN—Regione Puglia POR PUGLIA FESR‐FSE 2014/2020; Dottorati innovativi con caratterizzazione industrial—PON R&I 2014–2020; “Sensore bio‐elettronico usa‐e‐getta per l'HIV autoalimentato da una cella a combustibile biologica” (BioElSens&Fuel); SiMBiT—Single molecule bio‐electronic smart system array for clinical testing (Grant agreement ID: 824946); PMGB—Sviluppo di piattaforme meccatroniche, genomiche e bioinformatiche per l'oncologia di precisione—ARS01_01195‐PON “RICERCA E INNOVAZIONE” 2014–2020; Åbo Akademi University CoE “Bioelectronic activation of cell functions”; and CSGI are acknowledged for partial financial support.

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10.1002/elsa.202100216Lisenssi: CC BY

Electrochemical Science Adv - 2022 - Sarcina - Enzyme based field effect transistor State‐of‐the‐art and futureLopullinen julkaistu versio, 2,22 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi-fe202401314929

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title = "Enzyme based field effect transistor: State-of-the-art and future perspectives",

abstract = "The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices{\textquoteright} configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.",

keywords = "enzymes, extended gate configuration, field-effect transistors, modified electrodes, potentiometric sensors",

author = "Lucia Sarcina and Eleonora Macchia and Angelo Tricase and Cecilia Scandurra and Anna Imbriano and Fabrizio Torricelli and Nicola Cioffi and Luisa Torsi and Paolo Bollella",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Electrochemical Science Advances published by Wiley-VCH GmbH.",

year = "2023",

month = jun,

doi = "10.1002/elsa.202100216",

language = "English",

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T1 - Enzyme based field effect transistor

T2 - State-of-the-art and future perspectives

AU - Sarcina, Lucia

AU - Macchia, Eleonora

AU - Tricase, Angelo

AU - Scandurra, Cecilia

AU - Imbriano, Anna

AU - Torricelli, Fabrizio

AU - Cioffi, Nicola

AU - Torsi, Luisa

AU - Bollella, Paolo

PY - 2023/6

Y1 - 2023/6

N2 - The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices’ configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.

AB - The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices’ configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.

KW - enzymes

KW - extended gate configuration

KW - field-effect transistors

KW - modified electrodes

KW - potentiometric sensors

UR - https://www.scopus.com/pages/publications/85130538788

U2 - 10.1002/elsa.202100216

DO - 10.1002/elsa.202100216

M3 - Short survey

AN - SCOPUS:85130538788

SN - 2698-5977

VL - 3

JO - Electrochemical Science Advances

JF - Electrochemical Science Advances

IS - 3

M1 - e2100216

ER -

Enzyme based field effect transistor: State-of-the-art and future perspectives

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