Engineering tissue morphogenesis: taking it up a Notch

Laura A. Tiemeijer; Sami Sanlidag; Carlijn V.C. Bouten; Cecilia Sahlgren

doi:10.1016/j.tibtech.2022.01.007

Engineering tissue morphogenesis: taking it up a Notch

Laura A. Tiemeijer, Sami Sanlidag, Carlijn V.C. Bouten, Cecilia Sahlgren^*

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Lehtiartikkeli › Katsausartikkeli › vertaisarvioitu

9 Sitaatiot (Scopus)

58 Lataukset (Pure)

Abstrakti

Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

Alkuperäiskieli	Englanti
Sivut	945-957
Sivumäärä	13
Julkaisu	Trends in Biotechnology
Vuosikerta	40
Numero	8
DOI - pysyväislinkit	https://doi.org/10.1016/j.tibtech.2022.01.007
Tila	Julkaistu - elok. 2022
OKM-julkaisutyyppi	A2 Katsausartikkeli tiedejulkaisuussa (artikkeli)

Pääsy asiakirjaan

10.1016/j.tibtech.2022.01.007Lisenssi: CC BY

2022 Engineering tissue morphogenesis; taking it up a Notch (Tiemeijer and Sanlidag et al.) Trends Biotechnol_Version of recordLopullinen julkaistu versio, 1,93 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi-fe2022040126604

SignalSheets: Multilayer mechanosignalling in vascular homeostasis
Sahlgren, C. (Vastuullinen tutkija)
01/09/20 → 31/08/24
Projekti: Research Council of Finland/Other Research Councils
CellMech: Center of Excellence in Cellular Mechanostasis
Sahlgren, C. (Vastuullinen tutkija), Sistonen, L. (Vastuullinen tutkija), Eriksson, J. (Vastuullinen tutkija), Toivola, D. (Vastuullinen tutkija), Meinander, A. (Vastuullinen tutkija), Cheng, F. (Vastuullinen tutkija) & Jacquemet, G. (Vastuullinen tutkija)
01/03/19 → 29/02/24
Projekti: Foundation
BACE: Center of Excellence in Bioelectronic Activation of Cell Functions
Österbacka, R. (Vastuullinen tutkija), Sjöqvist, M. (CoPI), Sahlgren, C. (CoPI), Torsi, L. (CoPI), Lindfelt, M. (CoPI), Hellsten, L. (CoI), Tewari, A. (CoI), Luukkonen, A. (CoI), Martinez Klimova, E. (CoI), Schmit, A. (CoI), Eklund, A. (CoI) & Gounani, Z. (CoI)
01/03/19 → 31/12/23
Projekti: Foundation

Viittausmuodot

@article{18434f66096944428e9ef1e36b85baaf,

title = "Engineering tissue morphogenesis: taking it up a Notch",

abstract = "Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.",

keywords = "Notch signaling, Notch signaling modulation, tissue patterning, morphogenesis, ligand immobilization",

author = "Tiemeijer, {Laura A.} and Sami Sanlidag and Bouten, {Carlijn V.C.} and Cecilia Sahlgren",

year = "2022",

month = aug,

doi = "10.1016/j.tibtech.2022.01.007",

language = "English",

volume = "40",

pages = "945--957",

journal = "Trends in Biotechnology",

issn = "0167-7799",

publisher = "Cell Press",

number = "8",

}

TY - JOUR

T1 - Engineering tissue morphogenesis: taking it up a Notch

AU - Tiemeijer, Laura A.

AU - Sanlidag, Sami

AU - Bouten, Carlijn V.C.

AU - Sahlgren, Cecilia

PY - 2022/8

Y1 - 2022/8

N2 - Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

AB - Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

KW - Notch signaling

KW - Notch signaling modulation

KW - tissue patterning

KW - morphogenesis

KW - ligand immobilization

U2 - 10.1016/j.tibtech.2022.01.007

DO - 10.1016/j.tibtech.2022.01.007

M3 - Review Article or Literature Review

SN - 0167-7799

VL - 40

SP - 945

EP - 957

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 8

ER -

Engineering tissue morphogenesis: taking it up a Notch

Abstrakti

Pääsy asiakirjaan

Sormenjälki

Projektit

SignalSheets: Multilayer mechanosignalling in vascular homeostasis

CellMech: Center of Excellence in Cellular Mechanostasis

BACE: Center of Excellence in Bioelectronic Activation of Cell Functions

Viittausmuodot