Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes

Denys Mavrynsky; Jani Rahkila; Daniel Bandarra; Soraia Martins; Margarida Meireles; Maria José Calhorda; Ida J. Kovács; István Zupkó; Mikko M. Hänninen; Reko Leino

doi:10.1021/om400234p

Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes

Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, Reko Leino

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

4 Sitaatiot (Scopus)

Abstrakti

Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.

Alkuperäiskieli	Ei tiedossa
Sivut	3012–3017
Sivumäärä	6
Julkaisu	Organometallics
Vuosikerta	32
Numero	10
DOI - pysyväislinkit	https://doi.org/10.1021/om400234p
Tila	Julkaistu - 2013
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

Pääsy asiakirjaan

10.1021/om400234p

http://pubs.acs.org/doi/abs/10.1021/om400234p

Viittausmuodot

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title = "Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes",

abstract = "Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.",

author = "Denys Mavrynsky and Jani Rahkila and Daniel Bandarra and Soraia Martins and Margarida Meireles and {Jos{\'e} Calhorda}, Maria and Kov{\'a}cs, {Ida J.} and Istv{\'a}n Zupk{\'o} and H{\"a}nninen, {Mikko M.} and Reko Leino",

year = "2013",

doi = "10.1021/om400234p",

language = "Odefinierat/ok{\"a}nt",

volume = "32",

pages = "3012–3017",

journal = "Organometallics",

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publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes

AU - Mavrynsky, Denys

AU - Rahkila, Jani

AU - Bandarra, Daniel

AU - Martins, Soraia

AU - Meireles, Margarida

AU - José Calhorda, Maria

AU - Kovács, Ida J.

AU - Zupkó, István

AU - Hänninen, Mikko M.

AU - Leino, Reko

PY - 2013

Y1 - 2013

N2 - Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.

AB - Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.

U2 - 10.1021/om400234p

DO - 10.1021/om400234p

M3 - Artikel

SN - 0276-7333

VL - 32

SP - 3012

EP - 3017

JO - Organometallics

JF - Organometallics

IS - 10

ER -