Cytotoxic activity of some glycoconjugates including saponins and anthracyclines

Filip S. Ekholm; Ágnes Berényi; Lucas Lagerquist; Tiina Saloranta-Simell; István Zupkó; Gyula Schneider; János Wölfling; Reko Leino

doi:10.1016/j.carres.2012.03.017

Cytotoxic activity of some glycoconjugates including saponins and anthracyclines

Filip S. Ekholm, Ágnes Berényi, Lucas Lagerquist, Tiina Saloranta-Simell, István Zupkó, Gyula Schneider, János Wölfling, Reko Leino

Molekylääritieteen ja -tekniikan laboratorio

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

6 Sitaatiot (Scopus)

Abstrakti

Many different glycoconjugates, including saponins (e.g., hellebrin) and anthracyclines (e.g., doxorubicin), are known to display cytotoxic activities. In recent work, we have developed synthetic protocols for the synthesis of various glycoconjugates, focusing on glycosylation methods for different classes of biomolecules. Simultaneously a number of saponins and anthracyclines have been generated. In this note, the cytotoxic activities of these synthesized compounds are briefly addressed. (C) 2012 Elsevier Ltd. All rights reserved.

Alkuperäiskieli	Ei tiedossa
Sivut	295–298
Sivumäärä	4
Julkaisu	Carbohydrate Research
Vuosikerta	356
DOI - pysyväislinkit	https://doi.org/10.1016/j.carres.2012.03.017
Tila	Julkaistu - 2012
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

Keywords

Anthracyclines
Cytotoxic activity
Glycoconjugates
Saponins

Pääsy asiakirjaan

10.1016/j.carres.2012.03.017

Viittausmuodot

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title = "Cytotoxic activity of some glycoconjugates including saponins and anthracyclines",

abstract = "Many different glycoconjugates, including saponins (e.g., hellebrin) and anthracyclines (e.g., doxorubicin), are known to display cytotoxic activities. In recent work, we have developed synthetic protocols for the synthesis of various glycoconjugates, focusing on glycosylation methods for different classes of biomolecules. Simultaneously a number of saponins and anthracyclines have been generated. In this note, the cytotoxic activities of these synthesized compounds are briefly addressed. (C) 2012 Elsevier Ltd. All rights reserved.",

keywords = "Anthracyclines, Cytotoxic activity, Glycoconjugates, Saponins, Anthracyclines, Cytotoxic activity, Glycoconjugates, Saponins, Anthracyclines, Cytotoxic activity, Glycoconjugates, Saponins",

author = "Ekholm, {Filip S.} and {\'A}gnes Ber{\'e}nyi and Lucas Lagerquist and Tiina Saloranta-Simell and Istv{\'a}n Zupk{\'o} and Gyula Schneider and J{\'a}nos W{\"o}lfling and Reko Leino",

year = "2012",

doi = "10.1016/j.carres.2012.03.017",

language = "Odefinierat/ok{\"a}nt",

volume = "356",

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journal = "Carbohydrate Research",

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TY - JOUR

T1 - Cytotoxic activity of some glycoconjugates including saponins and anthracyclines

AU - Ekholm, Filip S.

AU - Berényi, Ágnes

AU - Lagerquist, Lucas

AU - Saloranta-Simell, Tiina

AU - Zupkó, István

AU - Schneider, Gyula

AU - Wölfling, János

AU - Leino, Reko

PY - 2012

Y1 - 2012

N2 - Many different glycoconjugates, including saponins (e.g., hellebrin) and anthracyclines (e.g., doxorubicin), are known to display cytotoxic activities. In recent work, we have developed synthetic protocols for the synthesis of various glycoconjugates, focusing on glycosylation methods for different classes of biomolecules. Simultaneously a number of saponins and anthracyclines have been generated. In this note, the cytotoxic activities of these synthesized compounds are briefly addressed. (C) 2012 Elsevier Ltd. All rights reserved.

AB - Many different glycoconjugates, including saponins (e.g., hellebrin) and anthracyclines (e.g., doxorubicin), are known to display cytotoxic activities. In recent work, we have developed synthetic protocols for the synthesis of various glycoconjugates, focusing on glycosylation methods for different classes of biomolecules. Simultaneously a number of saponins and anthracyclines have been generated. In this note, the cytotoxic activities of these synthesized compounds are briefly addressed. (C) 2012 Elsevier Ltd. All rights reserved.

KW - Anthracyclines

KW - Cytotoxic activity

KW - Glycoconjugates

KW - Saponins

KW - Anthracyclines

KW - Cytotoxic activity

KW - Glycoconjugates

KW - Saponins

KW - Anthracyclines

KW - Cytotoxic activity

KW - Glycoconjugates

KW - Saponins

U2 - 10.1016/j.carres.2012.03.017

DO - 10.1016/j.carres.2012.03.017

M3 - Artikel

SN - 0008-6215

VL - 356

SP - 295

EP - 298

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -