Computer modelling of the 3-dimensional structures of the cyanobacterial hepatotoxins microcystin-LR and nodularin

    Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

    36 Sitaatiot (Scopus)

    Abstrakti

    The 3-dimensional structures of two cyanobacterial hepatotoxins microcystin-LR, a cyclic heptapeptide and nodularin, a cyclic pentapeptide, and the novel amino acid ADDA (3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid) were constructed, and optimized using the CHEM-X molecular mechanics program. The peptide rings were planar and of rectangular shape. Optimized ADDA formed a U-shape and a difference in the orientation of ADDA with respect to the peptide ring of the two hepatotoxins was observed.
    AlkuperäiskieliEi tiedossa
    Sivut901–906
    JulkaisuToxicon
    Vuosikerta29
    Numero7
    TilaJulkaistu - 1991
    OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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