Abstrakti
The 3-dimensional structures of two cyanobacterial hepatotoxins microcystin-LR, a cyclic heptapeptide and nodularin, a cyclic pentapeptide, and the novel amino acid ADDA (3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid) were constructed, and optimized using the CHEM-X molecular mechanics program. The peptide rings were planar and of rectangular shape. Optimized ADDA formed a U-shape and a difference in the orientation of ADDA with respect to the peptide ring of the two hepatotoxins was observed.
Alkuperäiskieli | Ei tiedossa |
---|---|
Sivut | 901–906 |
Julkaisu | Toxicon |
Vuosikerta | 29 |
Numero | 7 |
Tila | Julkaistu - 1991 |
OKM-julkaisutyyppi | A1 Julkaistu artikkeli, soviteltu |